Registration Details
This NC3Rs NAMs Network event will focus on how new approach methodologies (NAMs)* can move from scientific innovation into real-world use in industry and regulatory decision making to replace the use of animals in safety testing.
The meeting will bring together method developers, regulators, industry, contract research organisations and policy stakeholders to explore the practical steps needed to accelerate uptake and implementation of NAMs across sectors. There will be a particular focus on capability building for method developers and progressing NAMs towards industry use and regulatory acceptance, recognising differences across sectors and regulatory regimes.
Poster abstracts are welcomed, submissions close: Tuesday 26 May.
Posters should showcase NAM development, updates on relevant initiatives supporting their application and uptake, case studies and collaboration calls. Abstracts can be submitted through the registration page (please sign in or create an NC3Rs website account to register).
Agenda
The meeting will be chaired by Camilla Alexander-White, MKTox Consultancy and chair of the NC3Rs Regulatory Sciences Forum.
There will be an opportunity for poster viewing and networking throughout the day.
Session one: Building partnerships and facilitating industry uptake
- Overview of the UK Government Strategy on Replacing Animals in Science
Anthony Holmes, NC3Rs/Office for Life Sciences (secondee) - Review of the UK preclinical model landscape and ensuring translational readiness.
Catherine Vickers, NC3Rs - Highlights from the NAMs Network In Conversation webinar on overcoming barriers to commercialisation
Helen Maddock (InoCardia Ltd), Marjolein Wildwater (Vivaltes), Victoria Hutter (ImmuONE) - Overviews from awardees of the NC3Rs/BBSRC Business Interaction Schemes on partnerships to progress method uptake
Jessica Ewald, Julia Mantaj, Ben Mellows, Katarzyna Pirog
Session two: Progressing towards regulatory acceptance
- Overview of OECD test method standardisation and adoption processes
TBC, UK Department for Environment, Food and Rural Affairs (Defra) - Update on the revision of OECD Guidance Document 34 on Validation and International Acceptance of New or Updated Test Methods for Hazard Assessment and new method readiness criteria, and standardisation of omics methods
Julia Malinowska, European Commission Joint Research Centre - Overview of the European Commission Roadmap towards phasing out animal testing for chemical safety assessments
Georg Streck, European Commission (virtual) - MHRA: regulation and reducing animal use in drug development
James McBlane, Medicines and Healthcare products Regulatory Agency - Contract Research Organisation perspective on validation and qualification
TBC
Session three: NAMs in action
- NAM-based frameworks for assessing endocrine activity in aquatic vertebrates: data driven case studies to support next steps
Julie Krzykwa, Health and Environmental Sciences Institute (HESI) - A case study with benzoic acid demonstrating how integration of in silico tools, mechanistic in vitro NAM, and toxicological data improves definition of point of departure for a chemically defined class in read-across assessments
Cathy Lester, Procter & Gamble (virtual) and Camilla Alexander-White, MKTox&Co - Other case studies
TBC
About the NC3Rs NAMs Network
The NC3Rs NAMs Network is a community of over 700 researchers, developers, industry end-users and regulators working to accelerate the use of new approach methodologies – replacement technologies for use in toxicology and safety assessment. Network events promote dialogue and information exchange between members, supporting the formation of new collaborations and sharing technologies and experience to maximise their scientific and 3Rs impact. We encourage stakeholders from across the NAMs sector to join the Network, where amongst other benefits you will receive early notification of relevant events and initiatives.
Learn more about Network activities, explore the benefits of becoming a member and sign up to the NC3Rs NAMs Network.
Registration information
Capacity for this event is limited and registrations will be confirmed on a first-come-first-served basis, please register early to secure your place. To ensure an effective and engaging event for all attendees, registrations will be checked for relevance to the NC3Rs NAMs Network remit. You do not need to be a Network member to register, but please note that this meeting is specifically for method developers, regulators, industry, contract research organisations and policy stakeholders with expertise in developing, validating and implementing new approach methodologies* in toxicology and regulatory sciences.
Please register for the event using an institutional email address. Registrations will be reviewed in line with our terms and conditions and policy on attendance at NC3Rs events (PDF).
* We use the term new approach methodologies specifically to refer to full and partial replacement approaches for assessing chemical or drug toxicity. Learn more about NAMs terminology.