Registration Details
James Barker and Esther Pearl, members of the NC3Rs Experimental Design and Reporting team, are taking part in a Responsible Research webinar on preclinical reporting.
Comprehensive reporting maximises the quality and reliability of published research and enables others to better scrutinise, evaluate and reproduce it, avoiding the wastage of animals and animal-derived materials in studies that are poor quality or not reproducible. To support best practice, the NC3Rs produced the ARRIVE guidelines for studies involving animals and the DRIVER recommendations for in vitro experiments.
This webinar will cover:
- Why preclinical reporting guidance is needed.
- How the ARRIVE guidelines and the DRIVER recommendations were developed, including the importance of broad engagement with the scientific community.
- How to use guidance when planning and reporting studies to improve reproducibility and reduce unnecessary animal use in preclinical research.
NC3Rs reporting resources
The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) are a checklist for the full and transparent reporting of research involving animals. The ARRIVE Essential 10 are the basic minimum that must be included in any manuscript describing animal research, without which readers and reviewers cannot assess the reliability of the findings. This is complemented by a Recommended Set of items that add important context and represent best practice. Since the initial launch in 2010, ARRIVE has become the international standard for reporting studies involving animals, endorsed by journals, funders, universities and other research organisations around the world.
The DRIVER recommendations (Designing and Reporting In Vitro Experiments Responsibly) set out six items covering key aspects of in vitro experimentation, including the identification and mitigation of potential sources of bias, model preparation, application of procedures, data handling and reporting. Together they establish a core set of principles for the experimental design and reporting of all in vitro models and methods. By supporting rigour in preclinical in vitro research, the DRIVER recommendations aim to build confidence in the use of cell-based models as alternatives to animal studies and avoid the wastage of animal-derived materials and reagents in poor quality in vitro studies that do not add to the knowledge base.