Registration Details
Delivered by regulatory specialists from Health and Safety Executive (HSE), this event will explore how to address toxicology information requirements for biocidal products without the use of vertebrate testing.
The session is aimed at technical and regulatory professionals involved in the preparation and submission of data into the GB biocidal product authorisation process. Talks will explore how submissions are assessed by the GB regulator and opportunities to submit data from new approach methodologies (NAMs) to assure human safety, replacing some tests involving rats, mice and rabbits.
Topics covered include:
- Introduction to the biocidal products toxicology information requirements and Article 62 of the GB Biocidal Products Regulation.
- How to minimise animal testing to provide toxicology information requirements for various human health endpoints, including: acute oral, dermal and inhalation toxicities, skin and eye irritation and skin sensitisation.
- The use of alternative approaches, such as the calculation method of CLP regulation and bridging/read across, and NAMs including in vitro and in silico methods.
- Practical guidance to improve the quality and compliance of applications.
Further information and resources from the NC3Rs
We are leading a number of projects to increase confidence in the use and application of NAMs for regulatory decision making, reducing the current reliance on animal toxicity tests and improving the science and predictivity of safety testing.
Learn more about new approach methodologies (NAMs) in toxicology.
Acute toxicity testing in animals involves death as the intended endpoint. We have provided recommendations to reduce animal numbers and minimise animal suffering through refinement where these tests are still used.
Learn more about reducing and refining acute toxicity tests.
Biocide testing also involves ecotoxicology studies to assure protection of wildlife and the environment. Our work in this area aims to provide an evidence base to refine and reduce the use of vertebrates, focusing on fishes.
Learn more about 3Rs opportunities in environmental safety testing.