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Model

Impact stories

6 results

Building confidence in non-protected zebrafish embryo-larvae as a viable alternative to mammalian DART assessment

Principal Investigator: Dr Jonathan Ball, University of Exeter

PhD Studentship

A 3Rs approach to assess drug toxicity on the mammalian embryo during early pregnancy in vitro

Principal Investigator: Dr David Turner, University of Liverpool

PhD Studentship

Validating CombiDART in the agrochemical sector

Contractor: Professor Alison Woollard, University of Oxford

CRACK IT Solution

Two non-vertebrate model systems, the nematode C. elegans and the social amoeba Dictyostelium discoideum to rapidly assess compounds for DART.

DARTpaths: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects

Contractor: Professor Raymond Pieters, University of Applied Sciences Utrecht (UASU)

CRACK IT Challenge

Novel biomarker platform for a 3Rs approach to assessment of developmental and reproductive toxicity

Principal Investigator: Dr Catherine Pears, University of Oxford

Project grant

PREDART: An integrative Dictyostelium, C. elegans and zebrafish approach to assess DART

Contractor: Professor Raymond Peters, University of Utrecht

CRACK IT Challenge