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Topic

Model

Impact stories

425 results

Development of novel models of kidney damage using induced human pluripotent stem cells

Principal Investigator: Dr Derek Brazil, Queen's University Belfast

PhD Studentship

Fusogenic liposomes: the innovative delivery of compounds into human platelets to reduce animal use in platelet research

Principal Investigator: Dr Alice Pollitt, University of Reading

PhD Studentship

Replacement of animal models of cardiac arrest and resuscitation strategies using a computer simulation

Principal Investigator: Professor Jonathan Hardman, University of Nottingham

PhD Studentship

Replacing Alzheimer's disease (AD) - Down syndrome (DS) mice with fly models

Principal Investigator: Dr Frances Wiseman, University College London

PhD Studentship

Fully humanised 3D vascular perfused model for breast cancer modelling and therapeutic screening

Principal Investigator: Professor Valerie Speirs, University of Aberdeen

Skills and Knowledge Transfer grant

Galleria mellonella as an infection model for viral pathogens

Principal Investigator: Professor Richard Titball, University of Exeter

Project grant

Professor Richard Titball sitting down observing a specimen

Experimental evolution of Pseudomonas aeruginosa in media replicating the conditions of the upper and lower airways

Principal Investigator: Dr Daniel Neill, University of Liverpool

PhD Studentship

Reducing number of mice required for drug testing via development of first in vitro automated screening platform of injured mammalian brain

Principal Investigator: Dr Veronique Miron, University of Edinburgh

PhD Studentship

Advanced in vitro and in silico models to predict and prevent deep venous thrombosis

Principal Investigator: Dr Alessio Alexiadis, University of Birmingham

PhD Studentship

Developing a rapid method for identification of key proteins that define tissues to create an array of tissue-specific hydrogels for human-relevant in vitro 3D culture

Principal Investigator: Professor Cathy Merry, University of Nottingham

Technologies to Tools grant

Transfer of the epicardial-cardiac organotypic culture model to support the ex vivo screening of gene therapy candidates

Principal Investigator: Dr Paola Campagnolo, University of Surrey

Skills and Knowledge Transfer grant

Dr Paola Campagnolo on the left with three colleagues on the right side of her in a laboratory

Assessing the relevance of Galleria mellonella to antibiotic drug discovery for pulmonary infections

Principal Investigator: Dr James Mason, King's College London

Skills and Knowledge Transfer grant

a photo showing a glass slide being held by a scientist, near to a microscope

An in vivo genetic screen of lung function candidate genes using tissue specific RNAi in Drosophila melanogaster

Principal Investigator: Dr Marios Georgiou, University of Nottingham

PhD Studentship

Replacing the need for patient-derived xenografts and matrigel organoid culture as preclinical models for breast cancer

Principal Investigator: Dr Robert Clarke, The University of Manchester

Skills and Knowledge Transfer grant

Platform to phenotype liver metabolic disorders

Principal Investigator: Professor Ludovic Vallier, University of Cambridge

Technologies to Tools grant

Dr Ludovic Vallier, winner of the 3Rs prize in 2011 can be seen sitting in a laboratory. He is wearing a white lab coat and purple gloves.

Translating microvascularised chips of a nephrotoxicity model

Principal Investigator: Dr Julien Gautrot, Queen Mary University of London

Technologies to Tools grant

From ageing to space travel: Developing an organotypic model of skeletal tissue disuse for understanding degeneration in altered environments

Principal Investigator: Dr Alexandra Iordachescu, University of Birmingham

Fellowship

Systems modelling age-related changes in the maintenance of dermal extra-cellular matrix: mechanisms and interventions

Principal Investigator: Dr Daryl Shanley, Newcastle University

Project grant

Validating alternative models to cats and dogs for heartworm drug testing

Principal Investigator: Dr Joseph Turner, Liverpool School of Tropical Medicine

Project grant

Drosophila model for muscular pain

Principal Investigator: Dr Olga Baron, King's College London

Fellowship