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Using exposure science to refine and reduce animal use, and support the uptake of new approach methodologies

Quarterly e-newsletter to keep the scientific community updated on news from the NC3Rs Toxicology and Regulatory Sciences programme.

Projects to ensure that the in vivo tests involved in ED assessment are as robust as possible, particularly focusing on aquatic species.

Resources and activities around NAMs (replacement technologies used to assess drug and chemical safety).

Join our community of researchers, developers, industry and regulatory end-users working together to accelerate the use of new approach methodologies.

Learn more about what NAMs are and how they can be applied to progress the 3Rs.

Key results and recommendations from an EPAA/MEB/NC3Rs collaboration focused on chronic toxicity studies for monoclonal antibodies (mAbs).

A webinar to highlight available opportunities to minimising non-human primate use in drug development.

Opportunities to reduce the use of non-human primates in toxicology programmes.

A webinar to raise awareness of the microsampling technique and encourage wider adoption.

A series of workshops as part of our project to implement the 3Rs in WHO guidelines.

Webinar showcasing ongoing and novel initiatives that replace, reduce and/or refine fish acute toxicity studies.

Reducing and refining acute toxicity tests in the pharmaceutical and chemicals industries.

Providing an evidence base to refine and reduce the use of vertebrates in (regulatory) ecotoxicology studies

Supporting the uptake of new approach methodologies to reduce reliance on traditional animal toxicity tests

Guidance on reducing or refining animal use for studies with cardiovascular, central nervous system and respiratory functional measurements.

Projects providing guidance to reduce animal use or refine procedures within toxicology studies.

Paper clarifies that the forced swim test is not a regulatory requirement for the development of new antidepressants (NC3Rs & MHRA project).

Key papers and resources on the topic of microsampling.