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NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research
Webinar and video

Workshop: Increasing confidence in New Approach Methodologies for regulatory decision-making

In collaboration with the British Toxicology Society and the Health and Safety Executive’s Chemicals Regulation Division, the NC3Rs hosted a two-day virtual workshop on 23-24 February 2022. The workshop was chaired by Professor John Colbourne, University of Birmingham and Professor Alan Boobis, Imperial College London.

The workshop aimed to raise awareness of currently available NAMs and explore how regulatory application and acceptance of these tools can be accelerated by overcoming the most significant barriers to their implementation. 

Recordings of the presentations and pdf copies of the slides can be found at the links below.

Session 1 - A vision for NAMs in safety testing

A vision for regulatory application of NAMs – personal reflections

Professor Alan Boobis, Imperial College London

(The slides can be found here).


Session 2 - OECD test method developments – current status of NAMs and lessons learnt

Overview of recently adopted NAM OECD guidelines and future workplan

Dr Anne Gourmelon, OECD

 (The slides can be found here)

Validation and standardisation of latest NAMs

Dr Nicole Kleinstreuer, NICEATM

(Slides not currently available)


Session 3 - Recent research developments in NAMs – Part I

Increasing confidence in chemical grouping using omics-derived molecular data

Professor Mark Viant, Michabo Health Science Ltd

(The slides can be found here)

Integrating in vitro bioactivity data, computational modelling and exposure science in animal-free cosmetic safety assessments

Dr Maria Baltazar, Unilever

(The slides can be found here).

Using (Q)SAR models as part of a weight of evidence, to reduce reliance on animal testing and support regulatory assessments

Dr Adrian Fowkes, Lhasa Ltd

(Slides not currently available).


Session 4 - Recent research developments in NAMs – Part II

Microphysiological systems – what is possible and what are the limitations?

Dr Jason Ekert, GSK

(Slides not currently available).

Importance of AOPs in NGRA – the case study of cardiotoxicity

Dr Luigi Margiotta-Casaluci, Kings College London

(The slides can be found here)

Novel in vivo mechanistic toxicology approaches to inform regulatory testing

Dr Francisco Inesta-Vaquera, University of Dundee

(The slides can be found here).


Session 5 - NAMs and regulatory needs

Barriers to and opportunities for the increased use of NAMs in the regulation of agrochemicals and biocides

Dr Susy Brescia, HSE CRD

(The slides can be found here)

Non-animal methods and new approach methodologies in UK REACH registration

Dr Helen McGarry, HSE CRD

(The slides can be found here).

The use of NAMs in regulatory assessments of cosmetics safety

Professor Qasim Chaudhry, University of Chester

(The recording is not available, slides can be found here).

Current and future role of NAMs in regulatory assessments of food

Dr David Gott, FSA

(The slides can be found here)

Acceptance of NAMs in the regulation of pharmaceuticals – what are the challenges and how they can be overcome

Dr David Jones, Independent

(The slides can be found here).