Dr Helen Prior

Position

Programme Manager – Drug development

LinkedIn

https://www.linkedin.com/in/helen-prior-aa060a95

Email address

helen.prior@nc3rs.org.uk


Helen is the lead for a collaboration with the ABPI on applying the 3Rs in pharmaceutical development. She is a member of the Toxicology and Regulatory Sciences team within the Science and Technology Group. 

View Helen's office-led projects.

External roles

NC3Rs publications

Prior H, Haworth R, Labram B, Roberts R, Sewell F and Wolfreys A (2020).  Justification for species selection for pharmaceutical toxicity studies. Toxicology Research (in press).  

Prior H, Baldrick P, Beken S, Booler H, Bower N, Brooker P, Brown P, Burlinson B, Burns-Naas L, Casey W, Chapman M, Clarke D, de Haan L, Doehr O, Downes N, Flaherty M, Gellatly N, Gry-Moesgaard S, Harris J, Holbrook M, Hui J, Jones D, Jones K, Kedar H, Mahl A, Manninen A, McGuire A, Mortimer-Cassen E, Peraza M, Pugsley M, Richard J, Roberts R, Roosen W, Rothfuss A, Schoenmakers A, Sewell F, Weaver R, Weir L, Wolfreys A and Kimber I (2020).  Opportunities for use of one species for longer-term toxicology testing during drug development: a cross-industry evaluation.  Regulatory Toxicology and Pharmacology 113: 104624. doi: 10.1016/j.yrtph.2020.104624. 

Jackson SJ, Authier S, Brohmann H, Goody S, Jones D, Prior H, Rosch A, Traebert M, Tse K, Valentin JP, Milne A (2019).  Neurofunctional test batteries in safety pharmacology – Current and emerging considerations for the drug development process.  Journal of Pharmacological and Toxicological Methods 100: 106602. doi: 10.1016/j.vascn.2019.106602.

Prior H, Monticello T, Boulifard V, Brennan FR, Kimber I (2019).  Integration of Consortia Recommendations for Justification of Animal Use Within Current and Future Drug Development Paradigms. International Journal of Toxicology 38: 319-325. doi: 10.1177/1091581819852922.

Skinner M, Ceuppens P, White P, Prior H (2019).  Social-housing and use of double-decker cages in rat telemetry studies.  Journal of Pharmacological and Toxicological Methods 96: 87-94 doi: 10.1016/j.vascn.2019.02.005.  

Prior H, Casey W, Kimber I, Whelan M, Sewell F (2019). Reflections on the progress towards non-animal methods for acute toxicity testing of chemicals.  Regulatory Toxicology and Pharmacology 102: 30-33. doi: 10.1016/j.yrtph.2018.12.008.  

Jackson S, Prior H, Holmes A (2018). The use of human tissue in safety assessment. Journal of Pharmacological and Toxicological Methods 93: 29 - 34 doi: 10.1016/j.vascn.2018.05.003

Prior H, Baldrick P, de Hann L, Downes N, Jones K, Mortimer-Cassen E, Kimber I (2018).  Reviewing the utility of two species in general toxicology related to drug development.  International Journal of Toxicology 37: 121-124. doi: 10.1177/1091581818760564.

Prior H, Sewell F, Stewart J (2017). Overview of 3Rs opportunities in drug discovery and development using non-human primates. Drug Discovery Today: Disease Models. 23: 11-16. doi: 10.1016/j.ddmod.2017.11.005

Sewell F, Edwards J, Prior H, Robinson S (2016). Opportunities to Apply the 3Rs in Safety Assessment Programs. ILAR Journal 57 (2): 234-245. doi: 10.1093/ilar/ilw024.

Prior H, Bottomley A, Champéroux P, Cordes J, Delpy E, Dybdal N, Edmunds N, Engwall M, Foley M, Hoffmann M, Kaiser R, Meecham K, Milano S, Milne A, Nelson R, Roche B, Valentin JP, Ward G, Chapman K (2016). Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies. Journal of Pharmacological and Toxicological Methods 81: 75-87. doi: 10.1016/j.vascn.2016.03.004

For publications, see Helen's ResearchGate profile.

Qualifications

UK and European Registered Toxicologist (ERT)
Accredited since 2019

Diplomate in Safety Pharmacology (DSP)
Accreditated since 2013

PhD, Cardiovascular Pharmacology
University of Leeds 1994 – 1997
K+ channel subtypes and adenosine A2A receptors in rabbit renal arcuate artery