Dr Helen Prior


Programme Manager – Drug development



Email address


Helen is the lead for a new collaboration with the ABPI on applying the 3Rs in pharmaceutical development. She is a member of the Toxicology and Regulatory Sciences team within the Science and Technology Group. Helen has previously collaborated on behalf of the Safety Pharmacology Society (SPS) on a project with the NC3Rs on social housing of non-rodents during telemetry studies.

View Helen's office-led projects.

External roles

NC3Rs publications

Skinner M, Ceuppens P, White P and Prior H (2019).  Social-housing and use of double-decker cages in rat telemetry studies.  Journal of Pharmacological and Toxicological Methods (in press) doi: 10.1016/j.vascn.2019.02.005.  

Prior H, Casey W, Kimber I, Whelan M and Sewell F (2019). Reflections on the progress towards non-animal methods for acute toxicity testing of chemicals.  Regulatory Toxicology and Pharmacology 102: 30-33. doi: 10.1016/j.yrtph.2018.12.008.  

Jackson S, Prior H and Holmes A (2018). The use of human tissue in safety assessment. Journal of Pharmacological and Toxicological Methods 93: 29 - 34 doi: 10.1016/j.vascn.2018.05.003

Prior H, Baldrick P, de Hann L, Downes N, Jones K, Mortimer-Cassen E and Kimber I (2018).  Reviewing the utility of two species in general toxicology related to drug development.  International Journal of Toxicology 37: 121-124. doi: 10.1177/1091581818760564.

Prior H, Sewell F, Stewart J (2017). Overview of 3Rs opportunities in drug discovery and development using non-human primates. Drug Discovery Today: Disease Models. (in press) doi: 10.1016/j.ddmod.2017.11.005

Sewell F, Edwards J, Prior H and Robinson S (2016). Opportunities to Apply the 3Rs in Safety Assessment Programs. ILAR Journal 57 (2): 234-245. doi: 10.1093/ilar/ilw024.

Prior H, Bottomley A, Champéroux P, Cordes J, Delpy E, Dybdal N, Edmunds N, Engwall M, Foley M, Hoffmann M, Kaiser R, Meecham K, Milano S, Milne A, Nelson R, Roche B, Valentin JP, Ward G, Chapman K (2016). Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies. Journal of Pharmacological and Toxicological Methods 81: 75-87. doi: 10.1016/j.vascn.2016.03.004

For publications, see Helen's ResearchGate profile.


PhD, Cardiovascular Pharmacology
University of Leeds 1994 – 1997
K+ channel subtypes and adenosine A2A receptors in rabbit renal arcuate artery