Dr Natalie Burden


Programme Manager – Toxicology and regulatory sciences, environmental safety



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Natalie leads our programmes on toxicology and regulatory sciences focusing on environmental testing. She is a member of the Science and Technology Group.

View Natalie's Office-led projects.

NC3Rs publications

Burden N, Benstead R, Benyon K, Clook M, Green C, Handley J, Harper N, Maynard SK, Mead C., Pearson A, Ryder K, Sheahan D, van Egmond R, Wheeler JR and Hutchinson TH. (2020), Key Opportunities to Replace, Reduce and Refine Regulatory Fish Acute Toxicity Tests. Environ Toxicol Chem. Accepted Author Manuscript. doi: 10.1002/etc.4824

Myatt GJ, Ahlberg E, Akahori Y et al. (2018). In silico toxicology protocols. Regulatory Toxicology and Pharmacology, epub ahead of print.  doi: 10.1016/j.yrtph.2018.04.014

Sewell F, Gellatly N, Beaumont M et al. (2018). The future trajectory of adverse outcome pathways: a commentary. Archives of Toxicology, 92(4):1657-1661. doi: 10.1007/s00204-018-2183-2

Burden N, Aschberger K, Chaudhry Q et al. (2017). Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long-term opportunities? Regulatory Toxicology and Pharmacology, 91:257-266. doi: 10.1016/j.yrtph.2017.10.021

Sewell F, Doe J, Gellatly N et al. (2017). Steps towards the international regulatory acceptance of non-animal methodology in safety assessment. Regulatory Toxicology and Pharmacology, 89:50-56. doi: 10.1016/j.yrtph.2017.07.001

Burden N, Gellatly N, Benstead R et al. (2017). Reducing repetition of regulatory vertebrate ecotoxicology studies. Integrated Environmental Assessment and Management, 13(5):955-957. doi: 10.1002/ieam.1934

Sewell F, Aggarwal M, Bachler G et al. (2017). The current status of exposure-driven approaches for chemical safety assessment: A cross-sector perspective. Toxicology, 389:109-117. doi: 10.1016/j.tox.2017.07.018

Burden N, Kendrick J, Knight L et al. (2017)Maximizing the success of bile duct cannulation studies in rats: Recommendations for best practice. Laboratory Animals, 51(5):457-464. doi:10.1177/0023677217698001

Burden N, Maynard SK, Weltje L, et al. (2017). Reducing the number of fish in regulatory bioconcentration testing: Identifying and overcoming the barriers to using the 1-concentration approach. Integrated Environmental Assessment and Management 13(1):212-214. doi:10.1002/ieam.1851

Burden N, Aschberger K, Chaudhry Q et al. (2017). The 3Rs as a framework to support a 21st century approach for nanosafety assessment. Nano Today 12:10-13. doi:10.1016/j.nantod.2016.06.007

Lillicrap A, Belanger S, Burden Net al. (2016). Alternative approaches to vertebrate ecotoxicity tests in the 21st century: A review of developments over the last 2 decades and current status. Environmental Toxicology and Chemistry. 35(11):2637-2646. doi:10.1002/etc.3603

Burden N, Maynard SK, Weltje L et al. (2016). The utility of QSARs in predicting acute fish toxicity of pesticide metabolites: A retrospective validation approach. Regulatory Toxicology and Pharmacology 80:241-246. doi:10.1016/j.yrtph.2016.05.032

Hutchinson TH, Wheeler JR, Gourmelon A et al. (2016). Promoting the 3Rs to enhance the OECD Fish Toxicity Testing Framework. Regulatory Toxicology and Pharmacology 76:231-233. doi:10.1016/j.yrtph.2016.02.006

Burden N, Chapman K, Sewell F, et al. (2015). Pioneering better science through the 3Rs: An introduction to the National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs). Journal of the American Association for Laboratory Animal Science 54(2):198-208. No doi, click to view.

Burden N, Benstead R, Clook M et al. (2015). Advancing the 3Rs in regulatory ecotoxicology: A pragmatic cross-sector approach. Integrated Environmental Assessment and Management 12(3):417-421. doi: 10.1002/ieam.1703

Burden N, Mahony C, Müller BP et al. (2015). Aligning the 3Rs with new paradigms in the safety assessment of chemicals. Toxicology 330: 62-66 doi: 10.1016/j.tox.2015.01.014

Burden N, Andersen ME, Boobis A et al. (2015). Adverse outcome pathways can drive non-animal approaches for safety assessment. Journal of Applied Toxicology 35(9):971-975 doi: 10.1002/jat.3165

Burden N, Chapman K, Sewell F (2015). Testing chemical safety: What is needed to ensure the widespread application of non-animal approaches? PLoS Biology 13(5):e1002156 doi: 10.1371/journal.pbio.1002156

Burden N and Hutchinson TH (2015). Benefits of the ARRIVE guidelines for improving scientific reporting in ecotoxicology. Environmental Toxicology and Chemistry 34(11):2446-2448 doi: 10.1002/etc.3111

Burden N, Creton S, Maynard SK et al. (2014). Reducing the number of fish in bioconcentration studies for general chemicals by reducing the number of test concentrations. Regulatory Toxicology and Pharmacology 70(2): 442-445 doi: 10.1016/j.yrtph.2014.08.008

For additional publications, see Natalie's ResearchGate profile.


Postgraduate Certificate (PGCert), Chemical Risk Assessment
Brunel University London, 2014-2016

PhD, Neurophysiology
Brighton and Sussex Medical School, 2009-2012
Electrophysiological mechanisms underlying the neuritis model of chronic pain.