Dr Natalie Burden
Natalie leads our strategy in accelerating the uptake and implementation of NAMs for safety assessment. She is a member of the Science and Technology Group.
View Natalie's Office-led projects.
External roles
- Coordinator of the BTS Ecotoxicology Speciality Section and member of the BTS Scientific Subcommittee.
- Member of the SETAC Animal Alternatives Interest Group steering team.
- Member of HESI Next Generation Ecological Risk Assessment Committee steering team.
- Member of the Innovative Medicines Initiative Prioritisation and Risk Evaluation of Medicines in the EnviRonment (PREMIER) project scientific advisory board.
- Member of the International Collaboration on Cosmetics Safety (ICCS) scientific advisory committee.
- Member of the International Consortium to Advance Cross Species Extrapolation in Regulation (ICACSER) steering team.
- NC3Rs representative for the UK Cross-Whitehall New Approaches to Chemical Risk Assessment in the Regulatory Space (NACRARS) group.
- Member of the EPAA Environmental Safety Assessment project team.
- Member of the NAM Journal editorial board.
- Member of the SETAC Endocrine Disruption Testing and Risk Assessment Interest Group steering committee.
NC3Rs publications
Burden N et al. (2024). Resource and animal use implications of the proposed REACH information requirements for endocrine disruptor assessment. Regulatory Toxicology and Pharmacology, 151:105671. doi: 10.1016/j.yrtph.2024.105671
Brown RJ et al. (2024). A decision logic for the reliability assessment and interpretation of vitellogenin measurements. Environmental Toxicology and Chemistry, 43(9):1933-1935. doi: 10.1002/etc.5946
Constantine LA et al. (2024). Evaluation of the EMA log kow trigger for fish BCF testing based on data for several human pharmaceuticals. Regulatory Toxicology and Pharmacology, 151:105651. doi: 10.1016/j.yrtph.2024.105651
Burden N et al. (2023). An international cross-laboratory survey on fish vitellogenin analysis: Methodological challenges and opportunities for best practice. Regulatory Toxicology and Pharmacology, 145:105501. doi: 10.1016/j.yrtph.2023.105501
Brown RJ et al. (2023). Are changes in vitellogenin concentrations in fish reliable indicators of chemical-induced endocrine activity?.Ecotoxicology and Environmental Safety, 266: 115563. doi: 10.1016/j.ecoenv.2023.115563
Mitchell CA et al. (2023). New approach methodologies for the endocrine activity toolbox: Environmental assessment for fish and amphibians. Environmental Toxicology and Chemistry, 42(4): 757–777. doi: 10.1002/etc.5584
Langan LM et al. (2023). Big question to developing solutions: A decade of progress in the development of aquatic new approach methodologies from 2012 to 2022. Environmental Toxicology and Chemistry, advance online publication. doi: 10.1002/etc.5578
Burden, N et al. (2022) Investigating endocrine-disrupting properties of chemicals in fish and amphibians: Opportunities to apply the 3Rs. Integrated Environmental Assessment and Management, 18(2) 442-458. doi: 10.1002/ieam.4497
Katsiadaki I et al. (2021) Dying for change: A roadmap to refine the fish acute toxicity test after 40 years of applying a lethal endpoint. Ecotoxicology and Environmental Safety, 223:112585. doi: 10.1016/j.ecoenv.2021.112585
Ortego LS et al. (2021) The Extended Amphibian Metamorphosis Assay: A thyroid-specific and less animal-intensive alternative to the Larval Amphibian Growth and Development Assay. Environmental Toxicology and Chemistry, 40(8):2135-2144. doi: 10.1002/etc.5078
Burden, N et al. (2021) Opportunities and challenges for integrating new in vitro methodologies in hazard testing and risk assessment. Small, 17(15):e2006298 doi: 10.1002/smll.202006298
Wheeler JR et al. (2021) Hormone data collection in support of endocrine disruption (ED) assessment for aquatic vertebrates: Pragmatic and animal welfare considerations. Environment International, 146:106287. doi: 10.1016/j.envint.2020.106287
Burden N et al. (2020) Key opportunities to replace, reduce and refine regulatory fish acute toxicity tests. Environmental Toxicology and Chemistry, 9(10):2076-2089. doi: 10.1002/etc.4824
Lagadic L et al. (2019) Recommendations for reducing the use of fish and amphibians in endocrine-disruption testing of biocides and plant protection products in Europe. Integrated Environmental Assessment and Management, 15(4), 659–662. doi: 10.1002/ieam.4156
Myatt GJ et al. (2018) In silico toxicology protocols. Regulatory Toxicology and Pharmacology, 96:1-17. doi: 10.1016/j.yrtph.2018.04.014
Sewell F et al. (2018) The future trajectory of adverse outcome pathways: a commentary. Archives of Toxicology, 92(4):1657-1661. doi: 10.1007/s00204-018-2183-2
Burden N et al. (2017) Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long-term opportunities? Regulatory Toxicology and Pharmacology, 91:257-266. doi: 10.1016/j.yrtph.2017.10.021
Sewell F et al. (2017) Steps towards the international regulatory acceptance of non-animal methodology in safety assessment. Regulatory Toxicology and Pharmacology, 89:50-56. doi: 10.1016/j.yrtph.2017.07.001
Burden N et al. (2017) Reducing repetition of regulatory vertebrate ecotoxicology studies. Integrated Environmental Assessment and Management, 13(5):955-957. doi: 10.1002/ieam.1934
Sewell F et al. (2017) The current status of exposure-driven approaches for chemical safety assessment: A cross-sector perspective. Toxicology, 389:109-117. doi: 10.1016/j.tox.2017.07.018
Burden N et al. (2017) Maximizing the success of bile duct cannulation studies in rats: Recommendations for best practice. Laboratory Animals, 51(5):457-464. doi:10.1177/0023677217698001
Burden N et al. (2017) Reducing the number of fish in regulatory bioconcentration testing: Identifying and overcoming the barriers to using the 1-concentration approach. Integrated Environmental Assessment and Management, 13(1):212-214. doi:10.1002/ieam.1851
Burden N et al. (2017). The 3Rs as a framework to support a 21st century approach for nanosafety assessment. Nano Today, 12:10-13. doi:10.1016/j.nantod.2016.06.007
Lillicrap A et al. (2016) Alternative approaches to vertebrate ecotoxicity tests in the 21st century: A review of developments over the last 2 decades and current status. Environmental Toxicology and Chemistry, 35(11):2637-2646. doi:10.1002/etc.3603
Burden N et al. (2016) The utility of QSARs in predicting acute fish toxicity of pesticide metabolites: A retrospective validation approach. Regulatory Toxicology and Pharmacology 80:241-246. doi:10.1016/j.yrtph.2016.05.032
Hutchinson TH et al. (2016) Promoting the 3Rs to enhance the OECD Fish Toxicity Testing Framework. Regulatory Toxicology and Pharmacology, 76:231-233. doi:10.1016/j.yrtph.2016.02.006
Burden N et al. (2015) Pioneering better science through the 3Rs: An introduction to the National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs). Journal of the American Association for Laboratory Animal Science, 54(2):198-208. PMCID: PMC4382625
Burden N et al. (2015) Advancing the 3Rs in regulatory ecotoxicology: A pragmatic cross-sector approach. Integrated Environmental Assessment and Management, 12(3):417-421. doi: 10.1002/ieam.1703
Burden N et al. (2015) Aligning the 3Rs with new paradigms in the safety assessment of chemicals. Toxicology, 330: 62-66. doi: 10.1016/j.tox.2015.01.014
Burden N et al. (2015) Adverse outcome pathways can drive non-animal approaches for safety assessment. Journal of Applied Toxicology, 35(9):971-975. doi: 10.1002/jat.3165
Burden N et al. (2015) Testing chemical safety: What is needed to ensure the widespread application of non-animal approaches? PLoS Biology, 13(5):e1002156. doi: 10.1371/journal.pbio.1002156
Burden N and Hutchinson TH (2015). Benefits of the ARRIVE guidelines for improving scientific reporting in ecotoxicology. Environmental Toxicology and Chemistry, 34(11):2446-2448. doi: 10.1002/etc.3111
Burden N et al. (2014) Reducing the number of fish in bioconcentration studies for general chemicals by reducing the number of test concentrations. Regulatory Toxicology and Pharmacology, 70(2): 442-445. doi: 10.1016/j.yrtph.2014.08.008
For additional publications, see Natalie's ResearchGate profile.
Qualifications
UK and European Registered Toxicologist (ERT)
Accredited since 2022
Postgraduate Certificate (PGCert), Chemical Risk Assessment
Brunel University London, 2014-2016
PhD, Neurophysiology
Brighton and Sussex Medical School, 2009-2012
Electrophysiological mechanisms underlying the neuritis model of chronic pain.