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NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research

Dr Nathalie Percie du Sert

Position
Head of Experimental Design and Reporting
Portrait of Dr Nathalie Percie du Sert

Nathalie is currently on maternity leave.

Nathalie leads our work on improving the design of animal research and its reporting in scientific publications. This includes both NC3Rs-funded research and animal research funded elsewhere. She is a member of the Policy and Outreach Group.

View Nathalie's Office-led projects

Other programmes of work

Experimental design

External roles

NC3Rs publications

Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen O, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Wurbel H (2020). The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol 18(7): e3000410. doi: 10.1371/journal.pbio.3000410

The ARRIVE guidelines 2.0 are also published in BMC Vet Res, BMJ Open Science, Br J Pharmacol, J Exp Physiol, J Cerebr Blood F Met, J Physiol and Vet Clin Pathol.

Percie du Sert N, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Hurst V, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen OH, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Wurbel H (2020). Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. PLoS Biol 18(7): e3000411. doi: 10.1371/journal.pbio.3000411

Koroshetz WJ, Behrman S, Brame CJ, Branchaw JL, Brown EN, Clark EA, Dockterman D, Elm JJ, Gay PL, Green KM, Hsi S, Kaplitt MG, Kolber BJ, Kolodkin AL, Lipscombe D, MacLeod MR, McKinney CC, Munafo MR, Oakley B, Olimpo JT, Percie du Sert N, Raman IM, Riley C, Shelton AL, Uzzo SM, Crawford DC, Silberberg SD (2020). Framework for advancing rigorous research. eLife 9 e55915. doi: 10.7554/eLife.55915

Huang W, Percie du Sert N, Vollert J, Rice ASC (2019). General principles of preclinical study design. Handbook of Experimental Pharmacology epub: 1-15. doi: 10.1007/164_2019_277

Percie du Sert N, Ahluwalia A, Alam S, Avey MT, Baker M, Browne W, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Hurst V, Karp NA, Lidster K, Maccallum CJ, Macleod M, Pearl EJ, Petersen O, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Würbel H (2019). Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019. bioRxiv 703355. doi: 10.1101/703355

Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lidster K, Maccallum CJ, Macleod M, Petersen O, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Würbel H (2019). The ARRIVE guidelines 2019: updated guidelines for reporting animal research. bioRxiv 703181. doi: 10.1101/703181

Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Altman DG, Avey MT, Baker M, Browne W, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Howells DW, Karp NA, MacCallum CJ, Macleod M, Petersen O, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Würbel H, Holgate ST (2018). Revision of the ARRIVE guidelines: rationale and scope. BMJ Open Sci 0:e000002. doi: 10.1136/bmjos-2018-000002

Percie du Sert N and Robinson V (2018). The NC3Rs gateway: Accelerating scientific discoveries with new 3Rs models and technologies. F1000Res 7:591. doi: 10.12688/f1000research.14964.1

Percie du Sert N, Bamsey I, Bate ST, Berdoy M, Clark RA, Cuthill IC, Fry D, Karp NA, Macleod M, Moon L, Stanford SC, Lings B (2017). The Experimental Design Assistant. Nat Meth 14: 1024-5 doi: 10.1038/nmeth.4462

Percie du Sert N, Bamsey I, Bate ST, Berdoy M, Clark RA, Cuthill IC, Fry D, Karp NA, Macleod M, Moon L, Stanford SC, Lings B (2017). The Experimental Design Assistant. PLoS Biol 15:e2003779. doi: 10.1371/journal.pbio.2003779

Percie du Sert N, Alfieri A, Allan SM, Carswell HVO, Deuchar GA, Farr TD, Flecknell P, Gallagher L, Gibson CL, Haley MJ, Macleod MR, Mccoll BW, Mccabe C, Morancho A, Moon LDF, O’Neill MJ, Pérez de Puig I, Planas A, Ragan CI, Rosell A, Roy LA, Ryder KO, Simats A, Sena ES, Sutherland BA, Tricklebank MD, Trueman RC, Whitfield L, Wong R, Macrae IM (2017). The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments). J Cereb Blood Flow Metab. doi: 10.1177/0271678X17709185

Munafò MR, Nosek BA, Bishop DVM, Button KS, Chambers CD, Percie du Sert N, Simonsohn, U, Wagenmakers, E-J, Ware, JJ, Ioannidis, JPA (2017). A manifesto for reproducible science. Nat Hum Behav 1: 0021. doi: 10.1038/s41562-016-0021

Percie du Sert N, Rice AS (2014) Improving the translation of analgesic drugs to the clinic: animal models of neuropathic pain. Br J Pharmacol 171(12): 2951-2963. doi: 10.1111/bph.12645

Percie du Sert N, Andrews PL (2014) The Ferret in Nausea and Vomiting Research: Lessons in Translation of Basic Science to the Clinic. In: Biology and Diseases of the Ferret, 3rd edition (Ed. Fox JG, Marini RP) John Wiley & Sons, Inc. doi: 10.1002/9781118782699.ch31

Percie du Sert N (2012). Maximising the output of osteoarthritis research: the ARRIVE guidelines. Osteoarthritis Cartilage 20(4): 253-5. doi: 10.1016/j.joca.2011.12.017

Percie du Sert N, Andrews PL, Holmes AM, Wallis R (2012). Predicting the emetic liability of novel chemical entities: a comparative study. Br J Pharmacol 165(6): 1848-67. doi: 10.1111/j.1476-5381.2011.01669.x

Percie du Sert N (2011). Systematic review and meta-analysis of pre-clinical research: the need for reporting guidelines. Eur Heart J 32(19): 2340. doi: 10.1093/eurheartj/ehr271 

Percie du Sert N (2011). Improving the reporting of animal research: when will we ARRIVE? Dis Model Mech 4(3): 281-2. doi: 10.1242/dmm.007971

NC3Rs blogs:

For additional publications, see Nathalie's ResearchGate profile.

Qualifications

PhD, Physiology
St George's University of London, 2005-2009
An investigation into the mechanism of cisplatin-induced emesis.

BSc Hons, Biology
Kingston University, London, 2001-2003

DEUG, Life Sciences
Université Claude Bernard Lyon I (France), 1999-2001