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New funding scheme: £4M available for proposals to establish infrastructure needed to accelerate use of non-animal methods. Apply now.

NC3Rs | 20 Years: Pioneering Better Science

£50M in replacement technologies

A collage of images to illustrate the work that the NC3Rs does. From top left to bottom right: A scientist in a white coat looks down a microscope, two whit rats sit in cardboard tubes, a cell plate, researchers standing around some equipment, a macaque sits on a swing, well plate with pink fluid, a technician moving animals between cages and a zebrafish tank showing three partial zebrafish swimming.

We have recently reached the important milestone of awarding over £50M to research to replace the use of animals.

We have funded the development of a range of complex in vitro and in silico models as well as supported the use of partial replacements through the use of so-called non-protected species such as the fruit fly, which based on current scientific thinking are not considered capable of suffering.

Read on to learn more about the outcomes and impacts arising from NC3Rs-funded replacement technologies including case studies from our grant holder's research.


£50M in replacement technologies



Case studies

Photograph of Dr Liz Ballou's lab

Fungal pathogen titanisation

Dr Elizabeth Ballou was awarded funding to validate an in vitro titanisation assay for Cryptococcus neoformans to build confidence in its utility to replace animal studies.

Portrait of Professor Aaron Maule

Growth and development of parasite worms in vitro

Professor Aaron Maule was awarded funding to further develop a culture method for liver fluke replacing the need to grow and develop the parasites rodents.

Photograph of Dr Gyorgy Fejer's lab

The lung's first line of defence

Dr Gyorgy Fejer was awarded funding to transfer skills and protocols to establish alveolar macrophage cell lines replacing the need to isolate cells from mouse organs or bone marrow.

Photograph of Professor Paul Langford's lab

Wax moths and tuberculosis research

Professor Paul Langford was awarded funding to develop a tuberculosis infection model using Galleria mellonella to replace the use of mammals in some studies.

For more information

Learn more about our funded awards focusing on replacing animals in research on our portfolio pages.