Organ-on-a-chip technologies

Organ-on-a-chip (OoC) technologies, also known as microphysiological systems (MPS) or tissue chips, are microfluidic cell culture devices that recapitulate the structure, function and (patho)physiology of human tissues and organs in vitro. They are promising tools to reduce the reliance on animal models in basic and applied research.

We support the development and uptake of OoC technology through a variety of mechanisms including:

  • Funding research and innovation.
  • Collaborating nationally and internationally.
  • Disseminating opportunities through our events and webinars.

Below you can find out more about our OoC activities as well as other global programmes and initiatives. The aim of these resources is to showcase our portfolio of projects in this area and provide information and support for the community, including technology developers, end-users, regulators and in vivo researchers who are looking to adopt alternative approaches. They include a report setting out our recommendations for supporting the development and wider adoption of the technology to maximise their 3Rs potential.

Find out more about funding opportunities and the OoC research we have funded.
Report summarising the current OoC landscape and our recommendations for supporting the technology's development and wider adoption.
Overview of past and ongoing OoC programmes and initiatives.
Working group to coordinate global efforts for the use of microphysiological systems to reduce reliance on in vivo studies of COVID-19.
Report summarising a joint OoC workshop and the key focus areas for the UK to advance the technology.
A showcase of organ-on-a-chip research funded by the NC3Rs highlighting the technology's scientific and 3Rs benefits.