Development of leucocyte cell lines for immunological research in teleost fish Principal Investigator: Dr Jun Zou, University of Aberdeen Project grant
Development of a mechanistically informative genome-wide, replacement chemicals screening technology Principal Investigator: Professor Andrew Cossins, University of Liverpool Project grant
Pseudoislets as a model system to study beta cell dysfunction in diabetes Principal Investigator: Professor Peter Jones, King's College London Project grant
Modelling the human asthmatic airway by tissue engineering Principal Investigator: Professor Donna Davies, University of Southampton Project grant
Replacement of hamsters with physicochemical analytical methods for Leptospira vaccine batch potency testing Principal Investigator: Dr Nicholas Coldham, Veterinary Laboratories Agency Project grant
A tissue engineering approach to reduce animal use in renal development and renal organ replacement technology Principal Investigator: Professor Jamie Davies, University of Edinburgh Project grant
Metabolically competent stem cell systems: novel means to implement 3Rs in better drug safety assessment Principal Investigator: Professor Roland Wolf, University of Dundee Project grant
An in vitro model of the human alveolus to predict the efficacy of systemic antifungal therapy Principal Investigator: Professor William Hope, University of Manchester Project grant
In vitro multi-chamber systems for studying neural degeneration processes Principal Investigator: Professor Victor Perry, University of Southampton Project grant
The use of honeybees to screen for toxins Principal Investigator: Dr Helen Thompson, Food and Environment Research Agency Project grant
An ex vivo mouse mandible culture model to study inflammatory bone disease Principal Investigator: Professor Alastair Sloan, Cardiff University Project grant
Development of alternatives to histamine sensitisation test for pertussis vaccines by in vitro biochemical and biological assays Principal Investigator: Dr Dorothy Xing, National Institute for Biological Standards and Control Project grant
Development of an in vitro model for the anterior region of the eye Principal Investigator: Dr Nigel Fullwood, Lancaster University Project grant
Development of a new human cell genotoxicity assay to reduce the use of live animals in drug development Principal Investigator: Professor Richard Walmsley, University of Manchester Project grant
Embryonic stem cell-derived cardiomyocytes as a model system for cardiac investigations Principal Investigator: Professor Sian Harding, Imperial College London Project grant
Development of an air-interface in vitro organ culture model (IVOC) of bovine respiratory epithelium Principal Investigator: Dr Alexander Tucker, University of Cambridge Project grant
Development of replacement in vitro assays for the quantification of clostridial vaccine antigens Principal Investigator: Dr Keith Redhead, Project grant
The development of a cell-based diabetic wound bioassay Principal Investigator: Professor David Thomas, Cardiff University Project grant
Replacement of the mouse bioassay: Development of SPE and LC-MS for detection of paralytic shellfish poisoning toxins Principal Investigator: Dr Elizabeth Turrell, Marine Scotland Science Project grant
Maintenance of Lutzomyia longipalpis colonies using an artificial membrane blood-feeding method Principal Investigator: Professor Richard Ward, Keele University Project grant