Galleria mellonella - a novel infection model for Mycobacterium tuberculosis aimed at reducing the number of animals in experimentation Principal Investigator: Professor Paul Langford, Imperial College London PhD Studentship
Identifying regulators of tissue regeneration by in vivo imaging in the zebrafish Principal Investigator: Dr Robert Knight, King's College London PhD Studentship
A chicken primary B cell culture model to study the pathogenesis and improve the control of immunosuppressive viruses of poultry Principal Investigator: Dr Andrew Broadbent, The Pirbright Institute Project grant
Ex vivo model for the study of epicardium-targeted therapies Principal Investigator: Dr Paola Campagnolo, University of Surrey Project grant
A comprehensive in silico approach to measure spatio-temporal changes of bone tissue in mouse models of osteoporosis and osteoarthritis Principal Investigator: Dr Enrico Dall'Ara, University of Sheffield Project grant
Intestinal organoids as a replacement strategy to unravel early host intestinal epithelia interactions with whipworms Principal Investigator: Dr Maria Duque Correa, Wellcome Trust Sanger Institute Fellowship
Developing human organotypic perfused bioreactors for physiologically reproducible therapeutic compound screening of a tumour microenvironment Principal Investigator: Dr Xiao Wan, University of Oxford Fellowship
The use of PrP transgenic Drosophila to replace and reduce mice in the bioassay of mammalian prions Principal Investigator: Dr Raymond Bujdoso, University of Cambridge Skills and Knowledge Transfer grant
In silico design and optimisation of novel host-directed therapies Principal Investigator: Dr Reiko Tanaka, Imperial College London PhD Studentship
Organoid and single cell models of bladder cancer Principal Investigator: Professor Margaret Knowles, University of Leeds PhD Studentship
In vitro reconstitution of the polymicrobial community associated with cystic fibrosis airway infections Principal Investigator: Dr Martin Welch, University of Cambridge PhD Studentship
Replacing liver cancer models by modeling human liver cancer in vitro Principal Investigator: Dr Meritxell Huch, University of Cambridge Project grant
Investigation of key inflammatory cells & mediators in zebrafish larval tailfin & heart repair/regeneration following resolution of inflammation Principal Investigator: Professor Adriano Rossi, University of Edinburgh PhD Studentship
Development of an AOP for cardiotoxicity mediated by the blockade of L-type calcium channel Principal Investigator: Dr Luigi Margiotta-Casaluci, Brunel University Strategic grant
High-throughput in vitro culture system for Cryptosporidium oocysts: replacing animals in research Principal Investigator: Professor Joanne Cable, Cardiff University Skills and Knowledge Transfer grant
Genetic screens in intestinal/colon organoid (mini-gut) culture using the CRISPR-Cas9 system Principal Investigator: Dr Abdolrahman Shams Nateri, University of Nottingham PhD Studentship
The establishment of left-right asymmetry in mammalian development Principal Investigator: Dr David Turner, University of Liverpool Fellowship
Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts Principal Investigator: Dr Anna Grabowska, University of Nottingham PhD Studentship
Training in hIPSC differentiation protocols to generate motor neuron-muscle cultures to replace rat models in study of mitochondria on axon physiology Principal Investigator: Dr Mark Rigby, King's College London Fellowship
A 3D in vitro glioblastoma cell culture system for identification and evaluation of novel radiosensitisers reducing rodent xenograft studies Principal Investigator: Professor Anthony Chalmers, University of Glasgow Project grant