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Topic

Model

Impact stories

631 results

Development of an AOP for cardiotoxicity mediated by the blockade of L-type calcium channel

Principal Investigator: Dr Luigi Margiotta-Casaluci, Brunel University

Strategic grant

Retinal 3D: 3D hiPSC derived laminated retinal model as a tool for toxicology studies

Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd

CRACK IT Challenge

Osteo-chip: Microfluidic Automated Platform for Osteoarthritis Drug Screening (MA-PODS)

Contractor: Professor Anne Dickinson, Alcyomics Ltd

CRACK IT Challenge

X-ray graphic of legs, the right leg has joint pain

High-throughput in vitro culture system for Cryptosporidium oocysts: replacing animals in research

Principal Investigator: Professor Joanne Cable, Cardiff University

Skills and Knowledge Transfer grant

Professor Joanne Cable sitting down beside a microscope

Non-invasive in vivo tissue imaging with functional optical coherence tomography (OCT)

Contractor: Professor Zhihong Huang, University of Dundee

CRACK IT Solution

Four 3D structual images of tissue of tissue imaging with functional optical coherence tomography

Modelling central and peripheral nervous system connectivity using compartmentalised microfluidic systems

Principal Investigator: Dr Federico Dajas-Bailador, University of Nottingham

PhD Studentship

Genetic screens in intestinal/colon organoid (mini-gut) culture using the CRISPR-Cas9 system

Principal Investigator: Dr Abdolrahman Shams Nateri, University of Nottingham

PhD Studentship

Dr Abdolrahman Shams Nateri with seven colleagues in white lab coats

Transfer of a non-human primate (NHP) in vitro functional assay for the early evaluation of TB vaccine candidates and the associated immune response

Principal Investigator: Dr Rachel Tanner, University of Oxford

Skills and Knowledge Transfer grant

Dr Rachel Tanner sitting down beside a microscope

Interrogating the mouse visual system by automated analysis of voluntary behaviour

Principal Investigator: Dr Riccardo Storchi, University of Manchester

Fellowship

Maximise: Integrated web platform for agro-chemical formulation toxicity classification and data sharing

Contractor: Professor Jonathan Timmis, SimOmics Ltd

CRACK IT Challenge

The establishment of left-right asymmetry in mammalian development

Principal Investigator: Dr David Turner, University of Liverpool

Fellowship

Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts

Principal Investigator: Dr Anna Grabowska, University of Nottingham

PhD Studentship

Neuroinflammation and nociception in a dish

Contractor: Professor Adalberto Merighi, University of Turin

CRACK IT Solution

Neuroinflammation and nociception in a dish

Training in hIPSC differentiation protocols to generate motor neuron-muscle cultures to replace rat models in study of mitochondria on axon physiology

Principal Investigator: Dr Mark Rigby, King's College London

Fellowship

A 3D in vitro glioblastoma cell culture system for identification and evaluation of novel radiosensitisers reducing rodent xenograft studies

Principal Investigator: Professor Anthony Chalmers, University of Glasgow

Project grant

Development of new experimental models to understand the genetic basis of allergic bronchopulmonary aspergillosis

Principal Investigator: Dr Sara Gago, University of Manchester

Fellowship

EASE: Design, Fabrication and Testing of a Mouse Embryo Culture Chip

Contractor: Dr Virginia Pensabene, University of Leeds

CRACK IT Challenge

An industrial standard cancer drug development platform using human induced pluripotent stem cell technology

Principal Investigator: Dr Deepali Pal, Newcastle University

Fellowship

Standardisation of preclinical PET/CT protocols across multiple research centres

Principal Investigator: Dr Adriana Tavares, University of Edinburgh

PhD Studentship

Automated predictive welfare assessment in groups of fish

Principal Investigator: Professor Oliver Burman, University of Lincoln

Project grant