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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

27 results

Replacement of in vivo arterial thrombosis models using human placental arteries: The birth of a new approach

Principal Investigator: Dr Sarah Jones, Manchester Metropolitan University

Project grant

Development of a fully humanised model for understanding platelet function

Principal Investigator: Dr Alice Pollitt, University of Reading

Project grant

Supporting 3Rs approaches in biologicals testing

Current contact: Dr Elliot Lilley

Office-led project

A human ex vivo model of haemostasis: A replacement for rodent tail bleeding assays

Principal Investigator: Dr Sarah Jones, Manchester Metropolitan University

Project grant

a photo showing a glass slide being held by a scientist, near to a microscope

Modelling of thrombus dynamics in a microfluidic 'vasculature'

Principal Investigator: Dr Nicola Mutch, University of Aberdeen

PhD Studentship

Portrait of Dr Whyte and Professor Mutch

Understanding how altered brain metabolism causes mitochondrial disease

Principal Investigator: Dr Joseph Bateman, King's College London

PhD Studentship

Understanding brain regeneration in a zebrafish larval model of intracerebral haemorrhage

Principal Investigator: Dr Siobhan Crilly, University of Manchester

Fellowship

Use of induced pluripotent stem cell derived cardiomyocytes to test the consequences of genetic variants in atrial and ventricular arrhythmias

Principal Investigator: Dr Katja Gehmlich, University of Birmingham

PhD Studentship

Two headshots side by side. On the left is Max, on the right is Dr Katja Gehmlich

Focused molecular understanding of hypertrophic cardiomyopathy using CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes

Principal Investigator: Dr Diogo Mosqueira, University of Nottingham

Fellowship

Development and characterization of a novel endothelialized in vitro model of human atherothrombosis

Principal Investigator: Dr Sarah Jones, Manchester Metropolitan University

PhD Studentship

Fusogenic liposomes: the innovative delivery of compounds into human platelets to reduce animal use in platelet research

Principal Investigator: Dr Alice Pollitt, University of Reading

PhD Studentship

Fully humanised 3D vascular perfused model for breast cancer modelling and therapeutic screening

Principal Investigator: Professor Valerie Speirs, University of Aberdeen

Skills and Knowledge Transfer grant

Transfer of the epicardial-cardiac organotypic culture model to support the ex vivo screening of gene therapy candidates

Principal Investigator: Dr Paola Campagnolo, University of Surrey

Skills and Knowledge Transfer grant

Dr Paola Campagnolo on the left with three colleagues on the right side of her in a laboratory

Replacing the need for patient-derived xenografts and matrigel organoid culture as preclinical models for breast cancer

Principal Investigator: Dr Robert Clarke, The University of Manchester

Skills and Knowledge Transfer grant

Using zebrafish embryos to identify genes that protect against atherosclerosis

Principal Investigator: Professor Paul Evans, University of Sheffield

PhD Studentship

Recreating thrombosis models using tissue-engineered arterial constructs: A novel method to reduce and replace mice used in platelet research

Principal Investigator: Dr Alan Harper, Keele University

PhD Studentship

Ex vivo model for the study of epicardium-targeted therapies

Principal Investigator: Dr Paola Campagnolo, University of Surrey

Project grant

Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts

Principal Investigator: Dr Anna Grabowska, University of Nottingham

PhD Studentship

A 3D in vitro glioblastoma cell culture system for identification and evaluation of novel radiosensitisers reducing rodent xenograft studies

Principal Investigator: Professor Anthony Chalmers, University of Glasgow

Project grant

Developing a zebrafish model of neurovascular coupling (NVC)

Principal Investigator: Dr Clare Howarth, University of Sheffield

Project grant