Inhalation Translation: Differentiating alveolar macrophage responses to inhaled medicines Contractor: Dr Ben Forbes, Kings College London, CRACK IT Challenge
Development of novel imaging agents for the prospective quantification of joint damage to reduce animal numbers in osteoarthritis research Principal Investigator: Professor Tonia Vincent, University of Oxford Project grant
Refining the mouse model of footpad immunisation and infection Principal Investigator: Dr Owain Millington, University of Strathclyde Pilot study grant
Mechanisms of intestinal epithelial responses to inflammatory modulators Principal Investigator: Professor Inke Nathke, University of Dundee Project grant
Development of human ex vivo bone-tumour niche for the study of cancer bone disease Principal Investigator: Dr James Edwards, University of Oxford Pilot study grant
Real-time monitoring techniques and simplistic platelet assays to reduce and refine animal use in cardiovascular and respiratory biomedical research Principal Investigator: Dr Michael Emerson, Imperial College London Project grant
Motor neuron regeneration in larval zebrafish Principal Investigator: Professor Catherina Becker, University of Edinburgh PhD Studentship
Exploitation of an ex vivo disease model to characterise early events in retinal degeneration Principal Investigator: Dr J. Arjuna Ratnayaka, University of Southampton PhD Studentship
Targeted, radiolabelled near-infrared quantum dots for high sensitivity and resolution, dual modality imaging of human tumours in mice Principal Investigator: Dr Anna Grabowska, University of Nottingham Strategic grant
Determining the source of variability within experimental stroke models Principal Investigator: Dr Claire Gibson, University of Leicester Pilot study grant
A novel product for reducing animal numbers in the production of transgenic mice Contractor: Ostara Biomedical Ltd, CRACK IT Solution
Developing molecular therapies for glaucoma using an ex vivo human organ culture system Principal Investigator: Professor Colin Willoughby, University of Liverpool PhD Studentship
Towards engineering a multi-cell lineage multi-organism intestine Principal Investigator: Dr Marc Veldhoen, Babraham Institute Cambridge PhD Studentship
3D gene knockout tissue models using adult human stem cells Principal Investigator: Professor Paul Genever, University of York PhD Studentship
DM-MAP: drug and metabolite microsampling analytical platform for preclinical medicines development Principal Investigator: Dr Darragh Murnane, University of Hertfordshire PhD Studentship
Development of a non-mammalian, pre-clinical screening tool (FETOX) for predictive analysis of drug safety Principal Investigator: Dr Grant Wheeler, University of East Anglia PhD Studentship
Development of a refined model of neuropathic pain: a model without frank nerve injury Principal Investigator: Dr Andrew Dilley, University of Sussex PhD Studentship
Development of a method for non-lethal sampling from individual fish to investigate host responses to ectoparasites Principal Investigator: Professor Chris Secombes, University of Aberdeen PhD Studentship
Non-invasive real-time bioluminescence imaging in living mice to interrogate transcription factor activity and fate of engrafted stem cells Principal Investigator: Dr Tristan McKay, Manchester Metropolitan University Strategic grant
Ultrasound mediated bioluminescence tomography for high sensitivity, high spatial resolution 3D imaging Principal Investigator: Professor Stephen Morgan, University of Nottingham Strategic grant