Cell based assay for tetanus vaccine and antitoxin production Principal Investigator: Professor Andrew Peden, University of Sheffield Project grant
Replacement of animal use in measuring cardiomyocyte response to drug safety profiling using a novel NMR metabolomics technology Principal Investigator: Dr Rachel Oldershaw, University of Liverpool PhD Studentship
INDUCE-seq: a novel tool for next generation risk assessment Principal Investigator: Professor Simon Reed, Cardiff University PhD Studentship
Drug risk assessment and repurposing using biomimetic chromatography and body-on-chip technology Principal Investigator: Dr Adriana Tavares, University of Edinburgh PhD Studentship
Development of non-mammalian, preclinical screening tools for the predictive analysis of cardiotoxicity Principal Investigator: Dr Grant Wheeler, University of East Anglia PhD Studentship
A 3Rs approach to assess drug toxicity on the mammalian embryo during early pregnancy in vitro Principal Investigator: Dr David Turner, University of Liverpool PhD Studentship
Validating CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes as tools to assist with toxicity profiling, adverse drug reaction notices and black box warnings Principal Investigator: Professor Chris Denning, University of Nottingham Technologies to Tools grant
Translating microvascularised chips of a nephrotoxicity model Principal Investigator: Dr Julien Gautrot, Queen Mary University of London Technologies to Tools grant
Developing an in vitro repeat-dose test as a 3Rs approach to detect non-genotoxic carcinogens Principal Investigator: Professor Gareth Jenkins, Swansea University PhD Studentship
Moving the Adverse Outcome Pathways Framework towards Practical Utility by Integrating Compound Profiling Data and Using Deep Learning Principal Investigator: Dr Andreas Bender, University of Cambridge PhD Studentship
Development of an AOP for cardiotoxicity mediated by the blockade of L-type calcium channel Principal Investigator: Dr Luigi Margiotta-Casaluci, Brunel University Strategic grant
Developing alternative models to evaluate the impact of nanomaterials on neutrophils during the stimulation and resolution of inflammation Principal Investigator: Dr Helinor Johnston, Heriot-Watt University Project grant
In silico human-based methodologies for evaluation of drug cardiac safety and efficacy Principal Investigator: Professor Blanca Rodriguez, University of Oxford Infrastructure grant
Novel biomarker platform for a 3Rs approach to assessment of developmental and reproductive toxicity Principal Investigator: Dr Catherine Pears, University of Oxford Project grant
Imprecision and importance: Probabilistic graphical models in toxicology Principal Investigator: Dr Jonathan Pitchford, University of York Strategic grant
Uncertainty and confidence in applying mathematical models and in vitro data in toxicological safety assessments Principal Investigator: Dr John Gosling, University of Leeds Strategic grant
Structural identifiability and indistinguishability analysis as tools for quantitative and systems pharmacology to support the 3Rs Principal Investigator: Dr Michael Chappell, University of Warwick Strategic grant
Human pluripotent stem cell cardiomyocytes and hepatocytes with engineered genotypes for drug safety evaluation Principal Investigator: Professor Chris Denning, University of Nottingham Project grant
Prediction of human cardiotoxic QT prolongation using in vitro multiple ion channel data and mathematical models of cardiac myocytes Principal Investigator: Dr Gary Mirams, University of Oxford Strategic grant
Combinatorial mathematical modelling & novel toxicological profiling of drug-induced hepatotoxicity Principal Investigator: Dr John Ward, Loughborough University PhD Studentship