Search our portfolio

Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

53 results

An iPSC based xeno-free platform to assess the foreign body response against new biomaterials

Principal Investigator: Professor Amir Ghaemmaghami, University of Nottingham

Project grant

T-ALERT: Developing an in vitro assay to evaluate the tumourigenicity of human engineered T cell therapies

Contractor: Professor Toni Cathomen, University of Freiburg

CRACK IT Challenge

Building confidence in non-protected zebrafish embryo-larvae as a viable alternative to mammalian DART assessment

Principal Investigator: Dr Jonathan Ball, University of Exeter

PhD Studentship

Cell based assay for tetanus vaccine and antitoxin production

Principal Investigator: Professor Andrew Peden, University of Sheffield

Project grant

a photo showing a glass slide being held by a scientist, near to a microscope

Virtual Second Species: Applying advanced computational and mathematical modelling approaches to develop a suite of virtual dog tissues and organs to model toxicological endpoints for new chemical entities

Contractor: Dr Stephan Schaller, esqLABS GmbH

CRACK IT Challenge

Virtual Second Species Challenge image of abstract network on a blue background

SAFE: Developing a suite of innovative bioassays to replace in vivo fish studies in chemical safety screening and regulatory environmental risk assessment.

Contractor: Dr Stephan Fischer, aQuaTox-Solutions GmbH

CRACK IT Challenge

Animal-free in vitro: Adapting established Organisation for Economic Development Test Guideline in vitro assays so that they are free from animal-derived products

Contractor: Dr Victoria Hutter, ImmuOne Ltd

CRACK IT Challenge

Animal free in vitro Challenge image of test tubes

In vitro TDAR: Developing a human in vitro T-cell dependent antibody response (TDAR) assay to assess immune enhancement

Contractor: Dr Karla Queiroz, Mimetas B.V.

CRACK IT Challenge

Challenge 35 in vitro TDAR image of antibodies

Replacement of animal use in measuring cardiomyocyte response to drug safety profiling using a novel NMR metabolomics technology

Principal Investigator: Dr Rachel Oldershaw, University of Liverpool

PhD Studentship

INDUCE-seq: a novel tool for next generation risk assessment

Principal Investigator: Professor Simon Reed, Cardiff University

PhD Studentship

Drug risk assessment and repurposing using biomimetic chromatography and body-on-chip technology

Principal Investigator: Dr Adriana Tavares, University of Edinburgh

PhD Studentship

Development of non-mammalian, preclinical screening tools for the predictive analysis of cardiotoxicity

Principal Investigator: Dr Grant Wheeler, University of East Anglia

PhD Studentship

A 3Rs approach to assess drug toxicity on the mammalian embryo during early pregnancy in vitro

Principal Investigator: Dr David Turner, University of Liverpool

PhD Studentship

Validating CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes as tools to assist with toxicity profiling, adverse drug reaction notices and black box warnings

Principal Investigator: Professor Chris Denning, University of Nottingham

Technologies to Tools grant

Translating microvascularised chips of a nephrotoxicity model

Principal Investigator: Dr Julien Gautrot, Queen Mary University of London

Technologies to Tools grant

Developing an in vitro repeat-dose test as a 3Rs approach to detect non-genotoxic carcinogens

Principal Investigator: Professor Gareth Jenkins, Swansea University

PhD Studentship

Moving the Adverse Outcome Pathways Framework towards Practical Utility by Integrating Compound Profiling Data and Using Deep Learning

Principal Investigator: Dr Andreas Bender, University of Cambridge

PhD Studentship

Development of an AOP for cardiotoxicity mediated by the blockade of L-type calcium channel

Principal Investigator: Dr Luigi Margiotta-Casaluci, Brunel University

Strategic grant

Developing alternative models to evaluate the impact of nanomaterials on neutrophils during the stimulation and resolution of inflammation

Principal Investigator: Dr Helinor Johnston, Heriot-Watt University

Project grant

In silico human-based methodologies for evaluation of drug cardiac safety and efficacy

Principal Investigator: Professor Blanca Rodriguez, University of Oxford

Infrastructure grant

Professor Blanca Rodriguez standing by a handrail