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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

425 results

Genetic screens in intestinal/colon organoid (mini-gut) culture using the CRISPR-Cas9 system

Principal Investigator: Dr Abdolrahman Shams Nateri, University of Nottingham

PhD Studentship

Dr Abdolrahman Shams Nateri with seven colleagues in white lab coats

Maximise: Integrated web platform for agro-chemical formulation toxicity classification and data sharing

Contractor: Professor Jonathan Timmis, SimOmics Ltd

CRACK IT Challenge

The establishment of left-right asymmetry in mammalian development

Principal Investigator: Dr David Turner, University of Liverpool

Fellowship

Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts

Principal Investigator: Dr Anna Grabowska, University of Nottingham

PhD Studentship

Neuroinflammation and nociception in a dish

Contractor: Professor Adalberto Merighi, University of Turin

CRACK IT Solution

Neuroinflammation and nociception in a dish

Training in hIPSC differentiation protocols to generate motor neuron-muscle cultures to replace rat models in study of mitochondria on axon physiology

Principal Investigator: Dr Mark Rigby, King's College London

Fellowship

A 3D in vitro glioblastoma cell culture system for identification and evaluation of novel radiosensitisers reducing rodent xenograft studies

Principal Investigator: Professor Anthony Chalmers, University of Glasgow

Project grant

Development of new experimental models to understand the genetic basis of allergic bronchopulmonary aspergillosis

Principal Investigator: Dr Sara Gago, University of Manchester

Fellowship

An industrial standard cancer drug development platform using human induced pluripotent stem cell technology

Principal Investigator: Dr Deepali Pal, Newcastle University

Fellowship

Standardisation of preclinical PET/CT protocols across multiple research centres

Principal Investigator: Dr Adriana Tavares, University of Edinburgh

PhD Studentship

Towards in vitro oncology trials: drug testing in cultured patient derived tumour organoid cultures

Principal Investigator: Professor Andrew Tutt, King's College London

Project grant

Inter-neuronal variability in human nociceptor electrophysiology: experimentally-driven computational study of response to drugs and channelopathies

Principal Investigator: Dr Oliver Britton, University of Oxford

Project grant

Unravelling the mechanism of transcellular chaperone signalling in C. elegans

Principal Investigator: Dr Patricija van Oosten-Hawle, University of Leeds

Project grant

Using chicken eggs to advance the 3Rs in cancer drug discovery

Contractor: Dr Jean Viallet

CRACK IT Solution

Injecting a chicken egg under a spotlight

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Demuris)

Contractor: Dr Olivia Champion, Biosystems Technology

CRACK IT Solution

Galleria mellonella larvaes in a green tub

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Envigo)

Contractor: Dr Olivia Champion, Biosystems Technology

CRACK IT Solution

Human tissue models for lung disease

Principal Investigator: Professor Maria Belvisi, Imperial College London

Infrastructure grant

Developing a zebrafish model of neurovascular coupling (NVC)

Principal Investigator: Dr Clare Howarth, University of Sheffield

Project grant

Developing alternative models to evaluate the impact of nanomaterials on neutrophils during the stimulation and resolution of inflammation

Principal Investigator: Dr Helinor Johnston, Heriot-Watt University

Project grant

Developing an Organ on a Chip Model to Test the Therapeutic Efficacy of Adhirons in Breast Cancer

Principal Investigator: Dr Darren Tomlinson, University of Leeds

PhD Studentship