Signalling pathways of leukocyte migration in silico Principal Investigator: Dr Juliane Liepe, Imperial College London Fellowship
PREDART: An integrative Dictyostelium, C. elegans and zebrafish approach to assess DART Contractor: Professor Raymond Peters, Institute for Risk Assessment Sciences/ Toxicology, U…, CRACK IT Challenge
Investigating tuberculosis by engineering human granulomas Principal Investigator: Dr Liku Tezera, University of Southampton Pilot study grant
Imprecision and importance: Probabilistic graphical models in toxicology Principal Investigator: Dr Jonathan Pitchford, University of York Strategic grant
Uncertainty and confidence in applying mathematical models and in vitro data in toxicological safety assessments Principal Investigator: Dr John Gosling, University of Leeds Strategic grant
An integrated platform to assay melanoblast and melanoma invasion of epidermis in vitro Principal Investigator: Dr Richard Mort, University of Edinburgh PhD Studentship
Structural identifiability and indistinguishability analysis as tools for quantitative and systems pharmacology to support the 3Rs Principal Investigator: Dr Michael Chappell, University of Warwick Strategic grant
Human pluripotent stem cell cardiomyocytes and hepatocytes with engineered genotypes for drug safety evaluation Principal Investigator: Professor Chris Denning, University of Nottingham Project grant
State of the art in vitro models which accurately predict human liver toxicity Contractor: Dr Dave Hay, CRACK IT Solution
Prediction of human cardiotoxic QT prolongation using in vitro multiple ion channel data and mathematical models of cardiac myocytes Principal Investigator: Dr Gary Mirams, University of Oxford Strategic grant
A new sensor platform combining plastic antibodies with simple thermal detection Contractor: Dr Marloes Peeters, CRACK IT Solution
Developing an in vitro approach to study transmission of respiratory viruses Principal Investigator: Professor Wendy Barclay, Imperial College London Project grant
Use of PrP transgenic Drosophila to measure mammalian prion infectivity Principal Investigator: Dr Raymond Bujdoso, University of Cambridge Project grant
eGUT: a Tool for Predictive Computer Simulation of the Gut Microbiota and Host Interactions Principal Investigator: Dr Jan-Ulrich Kreft, University of Birmingham Project grant
Improving the principles of the 3Rs through new integrative metabolomic and gene expression resources for signalling studies in burn injuries Principal Investigator: Dr Istvan Nagy, Imperial College London PhD Studentship
CRANNME: The complete removal of animal use for neuromuscular effectors testing Principal Investigator: Professor Mark Lewis, Loughborough University Pilot study grant
In vitro methods for replacement of current in vivo assays for development of drugs against heterogeneous cancer stem cell populations Principal Investigator: Dr Adrian Biddle, Queen Mary University of London Fellowship
The role of bronchoconstriction in the development of airway remodelling and its effects upon lung function Principal Investigator: Dr Amanda Tatler, University of Nottingham Fellowship
Optimising liver equivalents to model liver fibrosis Principal Investigator: Dr Fiona Oakley, Newcastle University Pilot study grant
Combinatorial mathematical modelling & novel toxicological profiling of drug-induced hepatotoxicity Principal Investigator: Dr John Ward, Loughborough University PhD Studentship