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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

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Topic

Model

Impact stories

425 results

State of the art in vitro models which accurately predict human liver toxicity

Contractor: Dr Dave Hay, University of Edinburgh

CRACK IT Solution

A 3D air-liquid interface airway epithelial cell model to study pathogen interactions within the bovine respiratory tract

Principal Investigator: Dr Robert Davies, University of Glasgow

Project grant

A stock image of round glass dishes containing blue and green liquid arranged closely together.

Non-invasive diffusion tracking in pharmacokinetics

Contractor: Dr Dan Daly, Lein Applied Diagnostics

CRACK IT Solution

A proof-of-concept device that is able to accurately and reproducibly measure the level and distribution of pharmaceuticals within the anterior chambers of excised porcine eyes with high spatial discrimination

Towards an in vitro system of predictive biomarkers of in vivo liposome efficacy

Principal Investigator: Dr Andrew Devitt, Aston University

Pilot study grant

Drosophila as a model to understand the role of glial cells in neurodegeneration

Principal Investigator: Dr Manolis Fanto, King's College London

Project grant

Replacement of murine transplantation assays by 3D in vitro substitutes for the assessment of therapeutic responses of cancer stem cells

Principal Investigator: Professor Ian MacKenzie, Queen Mary University of London

Project grant

Professor Ian MacKenzie with a colleague who is using a microscope in a laboratory

An in vitro model to investigate the role of oestrogen and oestrogen metabolism in pulmonary vascular disease

Principal Investigator: Professor Margaret MacLean, University of Glasgow

PhD Studentship

Applying the 3Rs to elucidate the mechanisms of tau pathology using DRG neurons in culture

Principal Investigator: Professor Maria Grazia Spillantini, University of Cambridge

Project grant

Novel approaches to immortalise salmon fish cells

Principal Investigator: Dr Bertrand Collet, Marine Scotland Science

Pilot study grant

Establishment of non-transformed, continuously growing, alternatively activated mouse macrophage cell lines

Principal Investigator: Dr Gyorgy Fejer, University of Southampton

Pilot study grant

Development of an in vitro screening system to minimise animal use in the search for factors that modulate (re)myelination

Principal Investigator: Dr Julia Edgar, University of Glasgow

Pilot study grant

Development of a sensitive in vitro system for anti-alpha-synuclein aggregation drug screening

Principal Investigator: Dr Maria Eugenia Herva Moyano, University of Cambridge

Fellowship

Dictyostelium as non-animal model to identify DNA repair pathways as targets for cancer therapy

Principal Investigator: Dr Nicholas Lakin, University of Oxford

PhD Studentship

Recapitulating the adult stem cell and cancer stem cell niche in vitro using 3D engineered matrices

Principal Investigator: Professor Christine Watson, University of Cambridge

PhD Studentship

A disease model to investigate vascular endothelial function for genetic stroke CADASIL

Principal Investigator: Dr Tao Wang, University of Manchester

PhD Studentship

Development of an in vitro culture system generating haematopoietic dendritic cells (DCs) from mouse embryonic stem cells

Principal Investigator: Dr Pierre Guermonprez, King's College London

PhD Studentship

Development of an in vitro system to determine the causes of aberrant, leukaemogenic V(D)J recombination reactions

Principal Investigator: Dr Joan Boyes, University of Leeds

PhD Studentship

Using molecular simulation to improve prediction of drug export

Principal Investigator: Dr Philip Biggin, University of Oxford

PhD Studentship

Live imaging of mucosal and vascular inflammation in zebrafish in response to a high cholesterol diet

Principal Investigator: Professor Margaret Dallman, Imperial College London

PhD Studentship

Using C. elegans to produce proteins from parasitic nematodes for research and therapeutic use

Principal Investigator: Dr David Weinkove, Durham University

Pilot study grant