Human and mouse artificial lymph nodes: novel technology to reduce and replace the use of animal models in clinical and developmental immunology Principal Investigator: Dr Mark Coles, University of York Project grant
The development of an in vitro model of spinal cord injury to study aligned neurite outgrowth Principal Investigator: Professor Susan Barnett, University of Glasgow PhD Studentship
Development of a non-animal model for characterizing drug-resistant tumours Principal Investigator: Professor Catherine Pears, University of Oxford PhD Studentship
A Drosophila model of Candida albicans gastrointestinal infection Principal Investigator: Professor Petros Ligoxygakis, University of Oxford PhD Studentship
Bone healing and regeneration in an ex vivo bioreactor – evaluation of angiogenesis and reparation for clinical application Principal Investigator: Professor Richard Oreffo, University of Southampton PhD Studentship
In vitro and in silico models of gut bacterial diversity and its impacts on human health Principal Investigator: Professor Timothy Barraclough, Imperial College London PhD Studentship
Optimisation of a flow-based human in vitro blood–brain barrier model to replace animal models for studying immunopathogenesis of viral brain infections Principal Investigator: Dr Adjanie Patabendige, University of Liverpool Fellowship
Reducing animal dependency in diabetes research through pancreatic stem cells Principal Investigator: Professor Mark Dunne, University of Manchester PhD Studentship
Construction of a miniaturised human lymph node model as an alternative to the Local Lymph Node Assay Principal Investigator: Professor Amir Ghaemmaghami, University of Nottingham PhD Studentship
Using induced pluripotent stem cells as a replacement for in vivo models to screen novel therapies which target self-renewal pathways in chronic myeloid leukaemia Principal Investigator: Dr Helen Wheadon, University of Glasgow PhD Studentship
Refining, reducing and replacing in vivo WHO-standard preclinical assays of snake venom pathology and antivenom efficacy Principal Investigator: Dr Robert Harrison, Liverpool School of Tropical Medicine PhD Studentship
Developing an integrated "in vitro carcinogenicity predictive tool" utilising in vitro cell signalling and cell behaviour assessment coupled with in vitro genotoxicity data Principal Investigator: Professor Gareth Jenkins, Swansea University Strategic grant
Development of human epithelial cell transformation models for carcinogen screening, employing defined phenotypic endpoints mechanistically representative of rate-limiting events in human carcinogenesis Principal Investigator: Professor Robert Newbold, Brunel University Strategic grant
An advanced model for neurodegeneration studies in the fruit fly Drosophila melanogaster Principal Investigator: Dr Ezio Rosato, University of Leicester Project grant
Replacement of animal models for tumour biology with a multifunctional microfluidic-based approach Principal Investigator: Professor John Greenman, University of Hull Project grant
Improving the predictive capacity of in vitro cytokine release assays to reduce animal use and drug attrition Contractor: Professor Martin Glennie, University of Southampton, CRACK IT Challenge
Development and mathematical modelling of zonated hollow fibre bioreactors for in vitro to in vivo extrapolation of systemic chemical toxicity Contractor: Dr Dominic Williams, University of Liverpool, CRACK IT Challenge
BADIPS: The development of cell lines relevant for the discovery of new treatments for bipolar affective disorder Contractor: Professor Andrew McIntosh, University of Edinburgh, CRACK IT Challenge
Pilot study investigating the use human stem cell derived neurons in toxicity testing Principal Investigator: Dr Eric Hill, Aston University Pilot study grant
Refining models of fibrotic lung disease Principal Investigator: Dr Gisli Jenkins, University of Nottingham Project grant