A novel product for reducing animal numbers in the production of transgenic mice Contractor: Dr Nadia Gopichandran, Ostara Biomedical Ltd CRACK IT Solution
Developing molecular therapies for glaucoma using an ex vivo human organ culture system Principal Investigator: Professor Colin Willoughby, University of Liverpool PhD Studentship
3D gene knockout tissue models using adult human stem cells Principal Investigator: Professor Paul Genever, University of York PhD Studentship
Development of a non-mammalian, pre-clinical screening tool (FETOX) for predictive analysis of drug safety Principal Investigator: Dr Grant Wheeler, University of East Anglia PhD Studentship
Molecularly Imprinted Nanoparticles (MIP NPs) as non-animal antibodies substitutes for detection of viruses Principal Investigator: Dr Alessandro Poma, University College London Fellowship
Development of a patient derived cellular model of circadian disruption in bipolar disorder Principal Investigator: Dr Sridhar Vasudevan, University of Oxford PhD Studentship
Contribution of autophagy to the maintenance, invasion and metastasis of melanoma stem-like sub populations. Principal Investigator: Dr David Hill, Newcastle University Fellowship
Find the target of valproic acid: pioneering the use of a non-animal model for basic biomedical (epilepsy) research Principal Investigator: Professor Robin Williams, Royal Holloway University of London PhD Studentship
Developing microfluidic systems for high throughput studies of functional neuronal networks Principal Investigator: Dr Michele Zagnoni, University of Strathclyde PhD Studentship
Labelled IMS TAG Proteins for Quantitative Mass Spectrometry Imaging Principal Investigator: Professor Malcolm Clench, Sheffield Hallam University Strategic grant
Generating zebrafish models of human eye movement disorders to replace mouse models Principal Investigator: Dr Ivana Poparic, King's College London Fellowship
Creating an in vitro model of pathogenic ossification to explore methods for dispersion Principal Investigator: Professor Liam Grover, University of Birmingham PhD Studentship
NephroTube: toxicity screening with a human renal cell line in a perfused titerplate Contractor: Northwestern Switzerland CRACK IT Challenge
VIDR: A multiscale model to minimise animal usage in Leishmaniasis drug development Contractor: Professor Paul Kaye, University of York CRACK IT Challenge
UnTangle: A microfluidics based drug-screening platform for human tau mutation neurons Contractor: Dr Selina Wray, University College London CRACK IT Challenge
InPulse: Engineered 2D & 3D hiPSC-CM platforms to detect cardiovascular safety liabilities Contractor: Professor Chris Denning, University of Nottingham CRACK IT Challenge
Replacing rodent models for investigating the influence of the microbiome upon innate immune responses and resistance to pathogens Principal Investigator: Dr Rachel Lawrence, Royal Veterinary College PhD Studentship
State of the art in vitro models which accurately predict human liver toxicity Contractor: Dr Dave Hay, University of Edinburgh CRACK IT Solution
A 3D air-liquid interface airway epithelial cell model to study pathogen interactions within the bovine respiratory tract Principal Investigator: Dr Robert Davies, University of Glasgow Project grant
Non-invasive diffusion tracking in pharmacokinetics Contractor: Dr Dan Daly, Lein Applied Diagnostics CRACK IT Solution