Imprecision and importance: Probabilistic graphical models in toxicology Principal Investigator: Dr Jonathan Pitchford, University of York Strategic grant
Uncertainty and confidence in applying mathematical models and in vitro data in toxicological safety assessments Principal Investigator: Dr John Gosling, University of Leeds Strategic grant
An integrated platform to assay melanoblast and melanoma invasion of epidermis in vitro Principal Investigator: Dr Richard Mort, University of Edinburgh PhD Studentship
Structural identifiability and indistinguishability analysis as tools for quantitative and systems pharmacology to support the 3Rs Principal Investigator: Dr Michael Chappell, University of Warwick Strategic grant
Human pluripotent stem cell cardiomyocytes and hepatocytes with engineered genotypes for drug safety evaluation Principal Investigator: Professor Chris Denning, University of Nottingham Project grant
Prediction of human cardiotoxic QT prolongation using in vitro multiple ion channel data and mathematical models of cardiac myocytes Principal Investigator: Dr Gary Mirams, University of Oxford Strategic grant
Developing an in vitro approach to study transmission of respiratory viruses Principal Investigator: Professor Wendy Barclay, Imperial College London Project grant
Use of PrP transgenic Drosophila to measure mammalian prion infectivity Principal Investigator: Dr Raymond Bujdoso, University of Cambridge Project grant
eGUT: a Tool for Predictive Computer Simulation of the Gut Microbiota and Host Interactions Principal Investigator: Dr Jan-Ulrich Kreft, University of Birmingham Project grant
Improving the principles of the 3Rs through new integrative metabolomic and gene expression resources for signalling studies in burn injuries Principal Investigator: Dr Istvan Nagy, Imperial College London PhD Studentship
CRANNME: The complete removal of animal use for neuromuscular effectors testing Principal Investigator: Professor Mark Lewis, Loughborough University Pilot study grant
In vitro methods for replacement of current in vivo assays for development of drugs against heterogeneous cancer stem cell populations Principal Investigator: Dr Adrian Biddle, Queen Mary University of London Fellowship
The role of bronchoconstriction in the development of airway remodelling and its effects upon lung function Principal Investigator: Dr Amanda Tatler, University of Nottingham Fellowship
Optimising liver equivalents to model liver fibrosis Principal Investigator: Dr Fiona Oakley, Newcastle University Pilot study grant
Combinatorial mathematical modelling & novel toxicological profiling of drug-induced hepatotoxicity Principal Investigator: Dr John Ward, Loughborough University PhD Studentship
Human and mouse artificial lymph nodes: novel technology to reduce and replace the use of animal models in clinical and developmental immunology Principal Investigator: Dr Mark Coles, University of York Project grant
The development of an in vitro model of spinal cord injury to study aligned neurite outgrowth Principal Investigator: Professor Susan Barnett, University of Glasgow PhD Studentship
Development of a non-animal model for characterizing drug-resistant tumours Principal Investigator: Professor Catherine Pears, University of Oxford PhD Studentship
A Drosophila model of Candida albicans gastrointestinal infection Principal Investigator: Professor Petros Ligoxygakis, University of Oxford PhD Studentship
Bone healing and regeneration in an ex vivo bioreactor – evaluation of angiogenesis and reparation for clinical application Principal Investigator: Professor Richard Oreffo, University of Southampton PhD Studentship