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Topic

Model

Impact stories

462 results

In vitro and in silico models of gut bacterial diversity and its impacts on human health

Principal Investigator: Professor Timothy Barraclough, Imperial College London

PhD Studentship

Optimisation of a flow-based human in vitro blood–brain barrier model to replace animal models for studying immunopathogenesis of viral brain infections

Principal Investigator: Dr Adjanie Patabendige, University of Liverpool

Fellowship

Reducing animal dependency in diabetes research through pancreatic stem cells

Principal Investigator: Professor Mark Dunne, University of Manchester

PhD Studentship

Construction of a miniaturised human lymph node model as an alternative to the Local Lymph Node Assay

Principal Investigator: Professor Amir Ghaemmaghami, University of Nottingham

PhD Studentship

Using induced pluripotent stem cells as a replacement for in vivo models to screen novel therapies which target self-renewal pathways in chronic myeloid leukaemia

Principal Investigator: Dr Helen Wheadon, University of Glasgow

PhD Studentship

Refining, reducing and replacing in vivo WHO-standard preclinical assays of snake venom pathology and antivenom efficacy

Principal Investigator: Dr Robert Harrison, Liverpool School of Tropical Medicine

PhD Studentship

A stock image of round glass dishes containing blue and green liquid arranged closely together.

Developing an integrated "in vitro carcinogenicity predictive tool" utilising in vitro cell signalling and cell behaviour assessment coupled with in vitro genotoxicity data

Principal Investigator: Professor Gareth Jenkins, Swansea University

Strategic grant

Development of human epithelial cell transformation models for carcinogen screening, employing defined phenotypic endpoints mechanistically representative of rate-limiting events in human carcinogenesis

Principal Investigator: Professor Robert Newbold, Brunel University

Strategic grant

An advanced model for neurodegeneration studies in the fruit fly Drosophila melanogaster

Principal Investigator: Dr Ezio Rosato, University of Leicester

Project grant

Replacement of animal models for tumour biology with a multifunctional microfluidic-based approach

Principal Investigator: Professor John Greenman, University of Hull

Project grant

Cytokines: Improving the predictive capacity of in vitro cytokine release assays to reduce animal use and drug attrition

Contractor: Professor Martin Glennie, University of Southampton

CRACK IT Challenge

IVIVE: Development and mathematical modelling of zonated hollow fibre bioreactors for in vitro to in vivo extrapolation of systemic chemical toxicity

Contractor: Dr Dominic Williams, University of Liverpool

CRACK IT Challenge

BADIPS: The development of cell lines relevant for the discovery of new treatments for bipolar affective disorder

Contractor: Professor Andrew McIntosh, University of Edinburgh

CRACK IT Challenge

Pilot study investigating the use human stem cell derived neurons in toxicity testing

Principal Investigator: Dr Eric Hill, Aston University

Pilot study grant

Refining models of fibrotic lung disease

Principal Investigator: Dr Gisli Jenkins, University of Nottingham

Project grant

A collection of test tubes containing coloured liquid

An in vitro model for pain and neurogenic inflammation in the oro-facial region and upper airways

Principal Investigator: Dr Fionnuala Lundy, Queen's University Belfast

PhD Studentship

Neonatal BCG vaccination: screening for genetic factors that influence host-pathogen interactions and reducing and replacing the requirement for animal infection models in immune mechanism discovery

Principal Investigator: Professor Melanie Newport, Brighton and Sussex Medical School

PhD Studentship

Highly differentiated cultures of ferret airway epithelium for the study of respiratory viruses, including influenza

Principal Investigator: Professor Wendy Barclay, Imperial College London

Project grant

Developing a platform of in vitro models of asthmatic and healthy lung: an alternative to the use of animals in asthma research

Principal Investigator: Dr Felicity Rose, University of Nottingham

Strategic grant

FIGCS: An in vitro model to replace ecotoxicity testing of fish to pharmaceuticals

Principal Investigator: Professor Christer Hogstrand, King's College London

Project grant