Search our portfolio

Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

462 results

MacuSIM: A microfluidic, in vitro model of the outer retina as an experimental platform for macular disease and therapeutic trials

Principal Investigator: Dr Savannah Lynn, University of Southampton

Fellowship

A novel tool that embeds 3Rs principles in multiple sclerosis research

Principal Investigator: Dr Julia Edgar, University of Glasgow

PhD Studentship

Validating CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes as tools to assist with toxicity profiling, adverse drug reaction notices and black box warnings

Principal Investigator: Professor Chris Denning, University of Nottingham

Technologies to tools grant

A computational framework to investigate the mechanical role of the extracellular matrix in tissue development and disease

Principal Investigator: Dr Nargess Khalilgharibi, University College London

Fellowship

A novel embryonic zebrafish model to replace mammals in the study of 3-hydroxyacyl CoA dehydratase 1-associated muscle disorders

Principal Investigator: Dr Rhiannon Morgan, University of Liverpool

Fellowship

Modelling O-GlcNAc transferase intellectual disability syndrome in Drosophila

Principal Investigator: Professor Daan van Aalten, University of Dundee

PhD Studentship

Engineering Galleria Mellonella as a model for infection, immunity and inflammation

Principal Investigator: Dr James Wakefield, University of Exeter

Project grant

CleanCut: Developing a human in vitro model to assess the safety of gene edited human haemopoietic stem cells

Contractor: Dr Alessandro Rotilio, MOAB srl

CRACK IT Challenge

A novel Drosophila platform to replace the use of mice and zebrafish for the study of ER-mitochondria interactions

Principal Investigator: Dr Alessio Vagnoni, King's College London

Partnerships and impact awards

Developing a chick embryo model to aid in development of personalised therapies for malignant pleural mesothelioma

Principal Investigator: Professor Judy Coulson, University of Liverpool

Project grant

Focused molecular understanding of hypertrophic cardiomyopathy using CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes

Principal Investigator: Dr Diogo Mosqueira, University of Nottingham

Fellowship

Development of an invertebrate model of alternating hemiplegia of childhood

Principal Investigator: Dr Steven Clapcote, University of Leeds

PhD Studentship

Development and characterization of a novel endothelialized in vitro model of human atherothrombosis

Principal Investigator: Dr Sarah Jones, Manchester Metropolitan University

PhD Studentship

An organotypic model of the bone remodelling process

Principal Investigator: Dr Amy Naylor, University of Birmingham

PhD Studentship

A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic model

Principal Investigator: Dr Adrian Biddle, Queen Mary University of London

PhD Studentship

Modelling Candida albicans infection of the human gut using human intestinal organoid cultures

Principal Investigator: Dr Silvia Gratz, University of Aberdeen

PhD Studentship

Maternal immune activation: advancing from rodents to humans through a development of a hIPSC model to study gene x environment interactions

Principal Investigator: Dr Anthony Vernon, King's College London

PhD Studentship

Development of novel models of kidney damage using induced human pluripotent stem cells

Principal Investigator: Dr Derek Brazil, Queen's University Belfast

PhD Studentship

Fusogenic liposomes: the innovative delivery of compounds into human platelets to reduce animal use in platelet research

Principal Investigator: Dr Alice Pollitt, University of Reading

PhD Studentship

Replacement of animal models of cardiac arrest and resuscitation strategies using a computer simulation

Principal Investigator: Professor Jonathan Hardman, University of Nottingham

PhD Studentship