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Activity type

Topic

Model

Impact stories

425 results

Validating CombiDART in the agrochemical sector

Contractor: Professor Alison Woollard, University of Oxford

CRACK IT Solution

Two non-vertebrate model systems, the nematode C. elegans and the social amoeba Dictyostelium discoideum to rapidly assess compounds for DART.

Characterising Mycobacterium tuberculosis in the human lung; developing new tools for antimicrobial drug discovery through the SH-TBL clinical trial

Principal Investigator: Professor Simon Waddell, University of Sussex

PhD Studentship

An alternative approach for assessing drug-induced seizures, using non-protected larval zebrafish

Principal Investigator: Professor Charles Tyler, University of Exeter

PhD Studentship

Insects as models to study the impact of antibiotics and microbiota therapies on the human gut microbiome: reducing the use of animals in research

Principal Investigator: Professor Anthony Maxwell, John Innes Centre

PhD Studentship

Developing and validating a computational model of the gut microbiota-mucosa interactions to replace and reduce animal experiments

Principal Investigator: Dr Jan-Ulrich Kreft, University of Birmingham

PhD Studentship

Developing an in vitro repeat-dose test as a 3Rs approach to detect non-genotoxic carcinogens

Principal Investigator: Professor Gareth Jenkins, Swansea University

PhD Studentship

Refining, reducing and replacing non-model amphibian experiments on amphibian infectious diseases

Principal Investigator: Dr Trenton Garner, Zoological Soc London Inst of Zoology

PhD Studentship

Using zebrafish embryos to identify genes that protect against atherosclerosis

Principal Investigator: Professor Paul Evans, University of Sheffield

PhD Studentship

Moving the Adverse Outcome Pathways Framework towards Practical Utility by Integrating Compound Profiling Data and Using Deep Learning

Principal Investigator: Dr Andreas Bender, University of Cambridge

PhD Studentship

Multiphoton imaging in human liver tissues: validation of a new tool for drug discovery

Principal Investigator: Dr Scott Davies, University of Birmingham

Fellowship

Recreating thrombosis models using tissue-engineered arterial constructs: A novel method to reduce and replace mice used in platelet research

Principal Investigator: Dr Alan Harper, Keele University

PhD Studentship

Replacing animal models in fungal pathogen research: An in vitro Titan virulence assay for the human fungal pathogen Cryptococcus neoformans

Principal Investigator: Dr Elizabeth Ballou, University of Birmingham

PhD Studentship

ImmuLiver – An immunologically-competent in vitro model of the human liver for the assessment of Yellow Fever vaccine attenuation

Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd

CRACK IT Challenge

Development of E-Sense: a flexible in vitro platform to determine cardiovascular risk

Principal Investigator: Dr Stephen White, Manchester Metropolitan University

PhD Studentship

A live model to study mucociliary clearance in health and disease

Principal Investigator: Professor David Thornton, University of Manchester

Project grant

A highly sensitive replacement assay for botulinum neurotoxin type B

Principal Investigator: Dr Andrew Peden, University of Sheffield

Project grant

DARTpaths: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects

Contractor: Professor Raymond Pieters, University of Applied Sciences Utrecht (UASU)

CRACK IT Challenge

A new sensor platform combining plastic antibodies with simple thermal detection

Contractor: Dr Marloes Peeters, Manchester Metropolitan University

CRACK IT Solution

Sensor platform combining plastic antibodies with simple thermal detection

Novel approach to model Non-Alcoholic Fatty Liver Disease using human Pluripotent Stem Cells

Principal Investigator: Dr Carola Morell, University of Cambridge

Fellowship

Generating in vitro human optic vesicles to dissect the genetic modifiers affecting ocular maldevelopment

Principal Investigator: Dr Mariya Moosajee, University College London

PhD Studentship