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Topic

Model

Impact stories

55 results

Multi-laboratory validation of a new animal product-free test guideline addition for the in vitro micronucleus test

Principal Investigator: Professor Victoria Hutter, University of Hertfordshire

Strategic grant

Validation of Scinora serum-free media formulations and Xplace supplement for the development of animal-free NAMs for nanotoxicology

Principal Investigator: Dr Fiona Murphy, University of Strathclyde

Strategic grant

An iPSC based xeno-free platform to assess the foreign body response against new biomaterials

Principal Investigator: Professor Amir Ghaemmaghami, University of Nottingham

Project grant

T-ALERT: Developing an in vitro assay to evaluate the tumourigenicity of human engineered T cell therapies

Contractor: Professor Toni Cathomen, University of Freiburg

CRACK IT Challenge

Building confidence in non-protected zebrafish embryo-larvae as a viable alternative to mammalian DART assessment

Principal Investigator: Dr Jonathan Ball, University of Exeter

PhD Studentship

Cell based assay for tetanus vaccine and antitoxin production

Principal Investigator: Professor Andrew Peden, University of Sheffield

Project grant

a photo showing a glass slide being held by a scientist, near to a microscope

Virtual Second Species: Applying advanced computational and mathematical modelling approaches to develop a suite of virtual dog tissues and organs to model toxicological endpoints for new chemical entities

Contractor: Dr Stephan Schaller, esqLABS GmbH

CRACK IT Challenge

Virtual Second Species Challenge image of abstract network on a blue background

SAFE: Developing a suite of innovative bioassays to replace in vivo fish studies in chemical safety screening and regulatory environmental risk assessment.

Contractor: Dr Stephan Fischer, aQuaTox-Solutions GmbH

CRACK IT Challenge

Animal-free in vitro: Adapting established Organisation for Economic Development Test Guideline in vitro assays so that they are free from animal-derived products

Contractor: Dr Victoria Hutter, ImmuOne Ltd

CRACK IT Challenge

Animal free in vitro Challenge image of test tubes

In vitro TDAR: Developing a human in vitro T-cell dependent antibody response (TDAR) assay to assess immune enhancement

Contractor: Dr Karla Queiroz, Mimetas B.V.

CRACK IT Challenge

Challenge 35 in vitro TDAR image of antibodies

Replacement of animal use in measuring cardiomyocyte response to drug safety profiling using a novel NMR metabolomics technology

Principal Investigator: Dr Rachel Oldershaw, University of Liverpool

PhD Studentship

INDUCE-seq: a novel tool for next generation risk assessment

Principal Investigator: Professor Simon Reed, Cardiff University

PhD Studentship

Drug risk assessment and repurposing using biomimetic chromatography and body-on-chip technology

Principal Investigator: Dr Adriana Tavares, University of Edinburgh

PhD Studentship

Development of non-mammalian, preclinical screening tools for the predictive analysis of cardiotoxicity

Principal Investigator: Dr Grant Wheeler, University of East Anglia

PhD Studentship

A 3Rs approach to assess drug toxicity on the mammalian embryo during early pregnancy in vitro

Principal Investigator: Dr David Turner, University of Liverpool

PhD Studentship

Validating CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes as tools to assist with toxicity profiling, adverse drug reaction notices and black box warnings

Principal Investigator: Professor Chris Denning, University of Nottingham

Technologies to tools grant

Translating microvascularised chips of a nephrotoxicity model

Principal Investigator: Dr Julien Gautrot, Queen Mary University of London

Technologies to tools grant

Developing an in vitro repeat-dose test as a 3Rs approach to detect non-genotoxic carcinogens

Principal Investigator: Professor Gareth Jenkins, Swansea University

PhD Studentship

Moving the Adverse Outcome Pathways Framework towards Practical Utility by Integrating Compound Profiling Data and Using Deep Learning

Principal Investigator: Dr Andreas Bender, University of Cambridge

PhD Studentship

Development of an AOP for cardiotoxicity mediated by the blockade of L-type calcium channel

Principal Investigator: Dr Luigi Margiotta-Casaluci, Brunel University

Strategic grant