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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

631 results

Acoustic Vocalisation Early Response Technologies (AVERT)

Principal Investigator: Dr Liane Hobson, MRC Harwell

Fellowship

From ageing to space travel: Developing an organotypic model of skeletal tissue disuse for understanding degeneration in altered environments

Principal Investigator: Dr Alexandra Iordachescu, University of Birmingham

Fellowship

Assessment of double ovulation to halve Xenopus laevis use for eggs

Principal Investigator: Professor Jeremy Green, King's College London

Project grant

Moshers: Mouse Smart Hoppers

Contractor: Dr Lawrence Moon, Research Devices Ltd

CRACK IT Challenge

Systems modelling age-related changes in the maintenance of dermal extra-cellular matrix: mechanisms and interventions

Principal Investigator: Dr Daryl Shanley, Newcastle University

Project grant

Rodent high-yield behavioural experiments

Current contact: Dr Chris Barkus

Office-led project

A black mouse in a plastic cage, standing on paper nesting material.

Validating alternative models to cats and dogs for heartworm drug testing

Principal Investigator: Dr Joseph Turner, Liverpool School of Tropical Medicine

Project grant

Drosophila model for muscular pain

Principal Investigator: Dr Olga Baron, King's College London

Fellowship

Implementation of non-aversive mouse handling for welfare refinement and reduction of mouse numbers

Principal Investigator: Dr John Roughan, Newcastle University

Skills and Knowledge Transfer grant

A novel murine model of squamous lung cancer

Principal Investigator: Dr Frank McCaughan, University of Cambridge

Project grant

Validating CombiDART in the agrochemical sector

Contractor: Professor Alison Woollard, University of Oxford

CRACK IT Solution

Two non-vertebrate model systems, the nematode C. elegans and the social amoeba Dictyostelium discoideum to rapidly assess compounds for DART.

Characterising Mycobacterium tuberculosis in the human lung; developing new tools for antimicrobial drug discovery through the SH-TBL clinical trial

Principal Investigator: Professor Simon Waddell, University of Sussex

PhD Studentship

An alternative approach for assessing drug-induced seizures, using non-protected larval zebrafish

Principal Investigator: Professor Charles Tyler, University of Exeter

PhD Studentship

Insects as models to study the impact of antibiotics and microbiota therapies on the human gut microbiome: reducing the use of animals in research

Principal Investigator: Professor Anthony Maxwell, John Innes Centre

PhD Studentship

Developing and validating a computational model of the gut microbiota-mucosa interactions to replace and reduce animal experiments

Principal Investigator: Dr Jan-Ulrich Kreft, University of Birmingham

PhD Studentship

Developing an in vitro repeat-dose test as a 3Rs approach to detect non-genotoxic carcinogens

Principal Investigator: Professor Gareth Jenkins, Swansea University

PhD Studentship

Refining, reducing and replacing non-model amphibian experiments on amphibian infectious diseases

Principal Investigator: Dr Trenton Garner, Zoological Soc London Inst of Zoology

PhD Studentship

Using zebrafish embryos to identify genes that protect against atherosclerosis

Principal Investigator: Professor Paul Evans, University of Sheffield

PhD Studentship

Refinement of soft tissue targeting and alignment protocols is small animal radiotherapy using an injectable fiducial marker

Principal Investigator: Dr Karl Butterworth, Queen's University Belfast

PhD Studentship

Moving the Adverse Outcome Pathways Framework towards Practical Utility by Integrating Compound Profiling Data and Using Deep Learning

Principal Investigator: Dr Andreas Bender, University of Cambridge

PhD Studentship