Non-invasive in vivo tissue imaging with functional optical coherence tomography (OCT) Contractor: University of Washington, CRACK IT Solution
Modelling central and peripheral nervous system connectivity using compartmentalised microfluidic systems Principal Investigator: Dr Federico Dajas-Bailador, University of Nottingham PhD Studentship
Genetic screens in intestinal/colon organoid (mini-gut) culture using the CRISPR-Cas9 system Principal Investigator: Dr Abdolrahman Shams Nateri, University of Nottingham PhD Studentship
Transfer of a non-human primate (NHP) in vitro functional assay for the early evaluation of TB vaccine candidates and the associated immune response Principal Investigator: Dr Rachel Tanner, University of Oxford Skills and Knowledge Transfer grant
Interrogating the mouse visual system by automated analysis of voluntary behaviour Principal Investigator: Dr Riccardo Storchi, University of Manchester Fellowship
Maximise: Integrated web platform for agro-chemical formulation toxicity classification and data sharing Contractor: Professor Jonathan Timmis, SimOmics Ltd, CRACK IT Challenge
The establishment of left-right asymmetry in mammalian development Principal Investigator: Dr David Turner, University of Liverpool Fellowship
Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts Principal Investigator: Dr Anna Grabowska, University of Nottingham PhD Studentship
Neuroinflammation and nociception in a dish Contractor: Professor Adalberto Merighi, CRACK IT Solution
Training in hIPSC differentiation protocols to generate motor neuron-muscle cultures to replace rat models in study of mitochondria on axon physiology Principal Investigator: Dr Mark Rigby, King's College London Fellowship
A 3D in vitro glioblastoma cell culture system for identification and evaluation of novel radiosensitisers reducing rodent xenograft studies Principal Investigator: Professor Anthony Chalmers, University of Glasgow Project grant
Development of new experimental models to understand the genetic basis of allergic bronchopulmonary aspergillosis Principal Investigator: Dr Sara Gago, University of Manchester Fellowship
EASE: Design, Fabrication and Testing of a Mouse Embryo Culture Chip Contractor: Dr Virginia Pensabene, University of Leeds, CRACK IT Challenge
An industrial standard cancer drug development platform using human induced pluripotent stem cell technology Principal Investigator: Dr Deepali Pal, Newcastle University Fellowship
Standardisation of preclinical PET/CT protocols across multiple research centres Principal Investigator: Dr Adriana Tavares, University of Edinburgh PhD Studentship
Automated predictive welfare assessment in groups of fish Principal Investigator: Professor Oliver Burman, University of Lincoln Project grant
Towards in vitro oncology trials: drug testing in cultured patient derived tumour organoid cultures Principal Investigator: Professor Andrew Tutt, King's College London Project grant
Inter-neuronal variability in human nociceptor electrophysiology: experimentally-driven computational study of response to drugs and channelopathies Principal Investigator: Dr Oliver Britton, University of Oxford Project grant
Unravelling the mechanism of transcellular chaperone signalling in C. elegans Principal Investigator: Dr Patricija van Oosten-Hawle, University of Leeds Project grant
Using chicken eggs to advance the 3Rs in cancer drug discovery Contractor: Dr Jean Viallet, CRACK IT Solution