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NC3Rs | 20 Years: Pioneering Better Science
Webinar and video

Re-evaluating the need for mAb chronic toxicity studies

This webinar was held in April 2023 in collaboration with the European Partnership for Alternative Approaches to Animal Testing (EPAA). Its aim is to provide an overview of the key results and recommendations emerging from a EPAA supported and funded project, focused on chronic toxicity studies for monoclonal antibodies (mAbs).

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Two journal publications from the project are discussed during the webinar:

Read more about this project on our resource page on Re-evaluating the need for mAb chronic toxicity studies.

Webinar agenda:

  • Welcome and brief background to the project
    Lucinda Weir, GSK, UK (CHAIR)
  • Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach
    Peter van Meer, Medicines Evaluation Board, The Netherlands
  • Recovery animal use and other 3Rs opportunities in nonclinical safety assessment studies with monoclonal antibodies
    Helen Prior, NC3Rs, UK
  • Panel discussion and audience Q&A
  • Concluding remarks
    Lucinda Weir, GSK, UK