An in vitro model system to assay kidney-pathogen interactions determining outcome of Candida albicans infection

Candida albicans is a human commensal organism that can cause life-threatening systemic infections in severely ill patients. The mouse intravenous challenge model is commonly used to model this infection. However, recent research has found that it is early events in the kidney that generate damaging immune responses and determine gross outcome of infection. Therefore, identification of the renal cells involved in these responses will allow development of an in vitro assay to model these events.

Mackie J et al. (2016). Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections. PloS One 11(6):e0158683. doi: 10.1371/journal.pone.0158683

Szabo EK and MacCallum DM (2014). A novel renal epithelial cell in vitro assay to assess Candida albicans virulence. Virulence 5(2):286-96. doi: 10.4161/viru.27046

Szabo EK and MacCallum DM (2011). The contribution of mouse models to our understanding of systemic candidiasis. FEMS Microbiol Lett 320(1):1-8. doi:10.1111/j.1574-6968.2011.02262.x

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PhD Studentship



Principal investigator

Dr Donna MacCallum


University of Aberdeen


Dr Carol Munro

Grant reference number


Award date

Oct 2010 - Sep 2014

Grant amount