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NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research

Our mission

A composite image representing the breadth of the 3Rs: a close-up of pipetting into a 96-well plate, black mice being handled using a plastic tube, and rows of zebrafish tanks

The NC3Rs works to pioneer better science through advancing the 3Rs in research.

Our mission is to:  

  • Support the discovery and adoption of predictive, reproducible and cost-effective alternatives to the use of animals.
  • Improve standards where animal use is necessary, optimising model selection and study design and minimising suffering as far as possible.
  • Promote the importance of the 3Rs across the scientific community, nationally and internationally, by providing training and embedding the 3Rs in policy, practice and regulations.
The NC3Rs was launched in 2004 in response to the House of Lords Select Committee report on Animals in Scientific Procedures, which recommended the establishment of a national centre to increase the focus on the 3Rs.

Who we work with

We collaborate with scientists and organisations from across the life sciences sector, nationally and internationally, including universities, industry, other research funders and regulatory authorities. These partnerships are essential for both the development of new 3Rs approaches and their implementation in practice.

Our engagement with the scientific community is varied including for example through the awards we make, the use of our online resources and attendance at our symposia and workshops. Many individuals and organisations input into our activities. Examples include:

  • Co-funding our grants and CRACK IT (e.g. from the MRC, BBSRC, EPSRC and Innovate UK).
  • Co-organising events (e.g. with the Royal Society for Biology, the Physiological Society and the British Pharmacological Society).
  • Membership of our expert working groups and funding panels (e.g. scientists from universities, pharmaceutical, chemical and consumer product companies and regulatory bodies).
  • Adopting our guidelines (e.g. funders such as the MRC, BBSRC, Wellcome Trust and the AMRC member charities, universities and journals).

We also work closely with professional bodies such as the Laboratory Animal Science Associations and the Institute for Animal Technology. Members of the NC3Rs team are involved in a wide range of committees and other external activities.

Our policy on animal research

The NC3Rs primary mission is to accelerate the replacement, reduction and refinement of the use of animals in research. As part of delivering this mission, the NC3Rs funds research which may involve the use of animals, for example to develop new imaging modalities and approaches that help reduce the use of animals or to establish new methods for assessing laboratory animal welfare.

The NC3Rs only supports the use of animals where the justification is scientifically compelling, where the experimental plans are robust and will provide meaningful results which are reported in line with the ARRIVE guidelines, and where appropriate measures are taken to minimise any suffering. Animal research supported by the NC3Rs must comply with the principles set out in Responsibility in the use of animals in bioscience research (PDF) and other guidance including specific terms and conditions associated with grant awards.

Wherever possible we ensure that animals are not used specifically for NC3Rs projects but instead "piggy-back" onto existing ongoing studies to minimise the use of animals. For our projects to develop tools and approaches that replace the use of animals it may be necessary to test these against animal models for comparative purposes. In the majority of these cases, historic animal data are used. 

Our services

We provide a 3Rs peer review and advice service to the UK's major funding bodies including the MRC, BBSRC, Wellcome Trust, and AMRC member charities.