Guidance document on opportunities to reduce and refine the use of GA mice through cryopreservation and sharing.
186 results
Reducing and refining acute toxicity tests in the pharmaceutical and chemicals industries.
Providing an evidence base to refine and reduce the use of vertebrates in (regulatory) ecotoxicology studies
Supporting the uptake of new approach methodologies to reduce reliance on traditional animal toxicity tests
Guidance on reducing or refining animal use for studies with cardiovascular, central nervous system and respiratory functional measurements.
Projects providing guidance to reduce animal use or refine procedures within toxicology studies.
External link
10 years of CRACK IT webinar: The Human In Vitro Gene Therapy Genotoxicity Testing service.
A webinar series from a cross-European group of 3Rs centres exploring the challenges and opportunities of replacing BMEs.
External link
A webinar exploring how environmental monitoring can replace the use of sentinel animals for monitoring mouse colonies for the presence of pathogens.
Information to help refine the housing and husbandry of the laboratory hamster.
External link
The evidence supporting the use of tunnel and cup handling to improve animal welfare and scientific outcomes (presented at AALAS 2021).
Details of the Rat Grimace Scale, including a poster for display in laboratory rooms and corridors.
Details of the Mouse Grimace Scale, including a poster for display in laboratory rooms and corridors.
External link
10 years of CRACK IT webinar: An IVF micro microfluidic device for non-surgical embryo transfer to generate transgenic mice.
Information to help refine the housing and husbandry of the laboratory dog.
A video resource for introductory training on the 3Rs aimed at in vivo researchers and animal technicians.
An introduction to systematic reviews, a powerful method used to assess accumulating evidence related to a specific research question.
External link
Reporting guidelines for animal experiments, and additional resources to support their use.
External link
An online tool to guide researchers through designing experiments involving the use of animals.
Tips to avoid common pitfalls when describing your experimental design and methodology in a funding proposal.
A dedicated, open access portal for our Grant holders to showcase their 3Rs research.
External link
10 years of CRACK IT webinar: A physiological-competent and predictive human 3D retinal cell model.
Resources on rat tickling and how it can be used to promote positive human-animal interactions.
Approaches for sampling blood in the hamster, covering non-surgical, surgical and terminal techniques.
