Innovations in translational models: Replacing in vivo models with complex cellular systems

As regulatory expectations evolve towards inclusion of new approach methodologies (NAMs) in safety assessment and the scientific community focuses on mechanism‑driven discovery research, this event from ELRIG’s UK Forum offers a timely forum to explore emerging replacement technologies that deliver greater physiological relevance to human biology.

Through expert talks, interactive discussions and technology demonstrations, attendees will gain a clear understanding of how next‑generation models, including organoids, microphysiological systems and co‑culture platforms, can be integrated into drug discovery pipelines.

The programme will deliver:

• A critical view of the latest complex cellular models, NAMs and non-animal technologies and their translational value.
• Practical strategies for replacing or reducing animal models while maintaining scientific robustness.
• Actionable insights on implementation, including assay design, validation considerations and operational challenges.

About ELIRG

ELRIG is a not-for-profit organisation bringing together the global life science and drug discovery industry at open-access, free-to-attend events. Find out more: elrig.org.

Dr Cathy Vickers (NC3Rs Head of Innovation) is a member of the ELRIG Science Committee and a Director of this ELRIG UK Forum, alongside Drs Emma Shepard (Aston University), Paul Roach (Loughborough University) and Eric Hill (Loughborough University).