Our board members

Professor Stephen Holgate CBE (Chair)

Professor Stephen Holgate CBE is an MRC Clinical Professor of Immunopharmacology and Honorary Consultant Physician within Medicine at the University of Southampton. His research focuses on the study of asthma and allied disorders using both epidemiological and genetic approaches.

In 2003 Stephen co-founded Synairgen, a publicly quoted respiratory drug development company, and in 2010 he was appointed as the Chair of the Research Excellence Framework (REF2014) Main Panel A covering Medicine, Health and Life Sciences. In addition to chairing the NC3Rs Board, he is a member of the Governing Board of the Nuffield Council of Bioethics, and until 2017 chaired the Hazardous Substances Advisory Committee. He is President of the British Association for Lung Research, and is a trustee of Cancer Research UK, the British Lung Foundation and the Kennedy Trust.

Stephen was appointed Commander of the Order of the British Empire (CBE) in the 2011 Queen’s New Year’s Honours.

Term ends: December 2019 | Declaration of interests (PDF)

Dr Paul Brooker

Following study at the University of East Anglia and University College London, Dr Paul Brooker worked for 33 years at Envigo, Europe’s largest preclinical contract research organisation. Beginning his work in the genetic toxicology group, Paul held a number of other positions, including Director of Toxicology, before finally taking up the role of President, EMEA (Europe, Middle East and Asia Pacific). In this role he was responsible for all of the scientific and breeding operations of Envigo across its 28 EMEA sites, involving over 3,000 scientific and technical staff across a range of disciplines.
Paul retired from Envigo in October 2016, but has continued his involvement in the biosciences. Currently he is a Member of the Executive Committee of the British Toxicology Society; Member of Council and Treasurer of the Royal Society of Biology; and Director, Board Member and Trustee of the Science Media Centre.

Term ends: December 2020 | Declaration of interests (PDF)

Professor Chris Denning

Professor Chris Denning is Head of the Department of Stem Cell Biology at the University of Nottingham. He leads the University's Research Priority Area in Regenerative Medicine & Stem Cells. His lab's interests are in cardiomyocyte differentiation of human pluripotent stem cells, focusing on three main areas: disease modelling, including CRISPR/Cas9; platforms for cardiotoxicity and drug evaluation; and automation of stem cell culture, differentiation and screening via interdisciplinary approaches.

Chris completed his PhD in Cancer Gene Therapy at the University of Glasgow, then undertook postdoctoral research at the University of Edinburgh and the Roslin Institute before joining the University of Nottingham. He is currently Chair of the NC3Rs Development and Impact Assessment Panel, and sits on the NC3Rs' 3Rs Prize Panel. He is also a member of the Editorial Board of Stem Cell Research and Stem Cells & Development. He has received two NC3Rs Project grants and a CRACK IT Challenge grant.

Term ends: December 2020 | Declaration of interests (PDF)

Dr Paul Finnemore

Dr Paul Finnemore is a veterinary surgeon, with postgraduate qualifications in laboratory animal science and business administration. He is the Chief Veterinary Officer (Head of Global Animal Research Assurance) for the AstraZeneca group of companies. He has previously served as an Inspector in the Animals in Science Regulation Unit (ASRU) at the Home Office, and as the Deputy Named Veterinary Surgeon at the University of Oxford.

Paul's key areas of expertise include laboratory animal veterinary medicine, the assessment and promotion of improvement in animal care programmes, and expert knowledge of the Animals (Scientific Procedures) Act 1986 and EU Directive 2010/63/EU. He is a Council Member of the Laboratory Animals Veterinary Association, Council Member of Understanding Animal Research, and an ad-hoc consultant to AAALAC International.

Term ends: December 2020 | Declaration of interests (PDF)

Professor Paul Garside

Professor Paul Garside is a member of the Wellcome Centre for Molecular Parasitology and a Professor of Immunobiology at the University of Glasgow. The key theme of his research is investigating the fundamentals of immune regulation in vivo and applying findings to infectious and autoimmune disease scenarios. He has been awarded funding for his research from a diverse range of organisations, including the MRC, the Wellcome Trust, the Scottish Government and the European Commission. He also has ongoing collaborations with several pharmaceutical companies including Bristol-Myers Squibb, AstraZeneca and Biogen.
In addition to his research and teaching commitments, Paul is a lead researcher on the Malawi Healthcare Project, a joint healthcare project linking the University of Glasgow and Malawi’s College of Medicine to investigate and overcome global health challenges. He is a Fellow of the Royal Society of Biology and the Royal Society of Edinburgh and is currently Chair of the NC3Rs' PhD Studentship Assessment Panel.

Term ends: December 2020 | Declaration of interests (PDF)

Professor Ian Jackson

Professor Ian Jackson studied Biochemistry at the University of Oxford, then completed his PhD in Genetics with Bob Williamson at St. Mary's Hospital in London, followed by postdoctoral work at the Carnegie Institution in Baltimore, USA. His research focuses on using mouse models to study how genetic mutations contribute to human and animal disease.

Ian is currently based at the University of Edinburgh, where he is Joint Section Head for Disease Mechanisms at the MRC Human Genetics Unit and is also a Group Leader at the Roslin Institute. He has been continuously funded by the MRC since 1991. He was elected a Fellow of the Royal Society of Edinburgh in 2008. He is also a member of the European Society for Pigment Cell Research Board, having been President from 2014 to 2017. He has previously been Chair of the NC3Rs' David Sainsbury Fellowship Assessment Panel and a member of the Grant Assessment Panel.

Term ends: December 2019 | Declaration of interests (PDF)

Dr David Lovell

Dr David Lovell is Reader in Medical Statistics and Associate Dean for Career Development of Research Staff at St George’s Medical School, University of London. His research focuses on facilitating the design, analysis and interpretation of a wide range of experimental and observational studies at St George’s. He has experience of working in both academia and industry, for organisations that include the University of Surrey, Pfizer, BIBRA and the Medical Research Council. He was also a Postdoctoral Fellow at the National Institute of Environmental Health Sciences in North Carolina USA.

David is currently Chair of the Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment and a Member of the Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment. He is also a member of the Editorial Boards of Biomarkers and Mutagenesis.

Term ends: December 2020 | Declaration of interests (PDF)

Professor Stefan Przyborski

Professor Stefan Przyborski has been a principal investigator at Durham University since 2000 and is currently Professor of Cell Technology. He studied Anatomy and Cell Biology at the University of Sheffield before completing a PhD there. He has specific interests in anatomy, tissue biology, cell differentiation, stem cells and the development of advanced technologies that enable the construction of human tissues in vitro.

Stefan is involved with the research, development and commercialisation of technology that enhances the environment in which cells are cultured in order to improve their growth, differentiation and function. In 2002 he founded Reinnervate (now ReproCELL Europe Ltd), a spin-out biotechnology company that develops 3D cell culture products. He is a Fellow of the Society of Biology and the Royal Society of Chemistry and President of the Anatomical Society. He chairs the NC3Rs' Grant Assessment Panel.

Term ends: December 2019 | Declaration of interests (PDF)

Professor Blanca Rodriguez

Professor Blanca Rodriguez is a Wellcome Trust Senior Research Fellow in Basic Biomedical Sciences and Professor of Computational Medicine at the University of Oxford. Her research focuses on the investigation of causes and modulators of variability in the response of the heart to disease and therapies, using computational modelling and simulation to expand and augment the information extracted from experimental and clinical methods used in cardiac electrophysiology. She is the recipient of three NC3Rs grants.

Blanca is a member of the e-cardiology Nucleus Group of the European Society of Cardiology and provides expert advice on in silico methods for toxicology and pharmacology assessment to industry and organisations such as the US Food and Drug Administration and the European Partnership for Alternative Approaches to Animal Testing. She also acts as Associate Editor of Pharmacology and Therapeutics and is a member of the Editorial Board of the open access journal PLoS ONE.

Term ends: December 2020 | Declaration of interests (PDF)

Professor Jon Timmis

Professor Jon Timmis is the Pro-Vice-Chancellor for Partnerships and Knowledge Exchange and Professor of Intelligent and Adaptive Systems in the Department of Electronic Engineering at the University of York. He is also the CEO of SimOmics Ltd, a spin-out company that provides cloud-based tools to support the 3Rs in testing, understanding toxicological risk and increased transparency of mathematical and computational models.
Jon's research is interdisciplinary and revolves around computational immunology and immuno-engineering, using swarm robotic systems as a platform for testing ideas relating to self-repairing autonomous systems. He leads the project team for the Maximise CRACK IT Challenge to develop an integrated web platform for agro-chemical formulation toxicity classification and data sharing.  He is a previous recipient of the Royal Society/Wolfson Research Merit Award and the Royal Academy of Engineering Enterprise Fellowship.

Term ends: December 2020 | Declaration of interests (PDF)

Professor Lucy Walker

Professor Lucy Walker is Chair of Immune Regulation at University College London's Institute of Immunity and Transplantation. She leads a research team investigating immune tolerance and autoimmunity, with a particular focus on type 1 diabetes. In September 2015 she was awarded a Royal Society Wolfson Research Merit Award. She currently holds grants from the Medical Research Council, the Horizon2020 Marie Skłodowska-Curie Innovative Training Network Programme and Diabetes UK.

Lucy is currently the Chair of the NC3Rs Training Fellowship Assessment Panel. She has also served on numerous other national and international funding committees including for the JDRF and the Wellcome Trust, and is a member of the Editorial Board for Clinical & Experimental Immunology and the Journal of Molecular Medicine. In September 2016 she was awarded the European Federation of Immunological Societies (EFIS) Lecture Award.

Term ends: December 2020 | Declaration of interests (PDF)

Dr Frances Rawle

Dr Frances Rawle represents the MRC on the NC3Rs Board.  She is Director of Policy and Governance at the MRC, a role which includes responsibility for governance and accountability for the MRC within UK Research and Innovation, and for development and implementation of policies in areas such as good research practice, research integrity, data sharing and transparency, research using personal data and research involving animals. She also has responsibility for research ethics and leads the MRC’s work aimed at improving reproducibility in biomedical research. 

Declaration of interests (PDF)

Dr Sadhana Sharma

Dr Sadhana Sharma represents the BBSRC on the NC3Rs Board. She is the Interim Head of Strategy for Bioscience for Health at the BBSRC and is responsible for leadership and coordination of this strategic area, which encompasses Lifelong Health, Nutrition for Health, One Health and Biotechnology for Health.

Declaration of interests (PDF)

Dr Vicky Robinson CBE

Dr Vicky Robinson CBE is the Chief Executive of the NC3Rs. For more information, please see her staff page.