Mature human iPSC-derived atrial cardiomyocytes to replace animals in the study of atrial fibrillation Principal Investigator: Dr Patrizia Camelliti, University of Surrey PhD Studentship
Developing patient derived tumour organoids to replace mouse models in understanding and improving anti-tumour T cell responses Principal Investigator: Dr Emma Reeves, University of Southampton PhD Studentship
Organ-on-a-chip modelling of respiratory-vascular cell-cell communication in Chronic Obstructive Pulmonary Disease (COPD) Principal Investigator: Professor Beata Wojciak-Stothard, Imperial College London PhD Studentship
Validating methods to cryopreserve, store and revive human precision cut tissue slices for disease modelling and drug testing Principal Investigator: Professor Fiona Oakley, Newcastle University PhD Studentship
Accelerate adoption of engineered vascular tissues with induced pluripotent stem cell-derived smooth muscle cells Principal Investigator: Professor Manuel Mayr, Imperial College London Partnerships and impact awards
Using a defined 3D human organoid model to replace the use of animals in the screening and evaluation of treatments for prostate cancer Principal Investigator: Dr Adriana Buskin, Newcastle University PhD Studentship
Integrated training and data sharing to accelerate adoption of 3Rs technology in trypanosome infection research Principal Investigator: Dr Catarina Gadelha, University of Nottingham Partnerships and impact awards
Goodbye gavage – Replacing oral gavage for mouse glucose tolerance testing Principal Investigator: Professor Kate Ellacott, University of Exeter Partnerships and impact awards
Re: Modification and validation of a human endothelialised in-vitro thrombosis model to promote end-user uptake Principal Investigator: Dr Sarah Jones, Manchester Metropolitan University Partnerships and impact awards
Development of a minimally-invasive ultrasound guided rat myocardial infarction model to replace the gold standard invasive thoracotomy approach Principal Investigator: Dr Mark MacAskill, University of Edinburgh PhD Studentship
Using a novel human 3D spheroid model to study mechanisms and therapeutics for vascular calcification Principal Investigator: Professor Cathy Shanahan, King's College London PhD Studentship
The characterization and application of tamoxifen taste masked beads in preclinical research Principal Investigator: Richard Houghton, University of Cambridge Partnerships and impact awards
Validating human lymphoid organoids and explants as 3Rs methods to reduce and replace animal use in immunology research Principal Investigator: Dr Pablo Céspedes, University of Oxford Partnerships and impact awards
Adoption of a long-term in vitro bone model to facilitate investigations into cancer dormancy and bone metastasis Principal Investigator: Professor Helen Wheadon, University of Glasgow Partnerships and impact awards
Replacement of in vivo arterial thrombosis models using human placental arteries: The birth of a new approach Principal Investigator: Dr Sarah Jones, Manchester Metropolitan University Project grant
Developing an in vitro model to investigate the role of the immune system in age-related macular degeneration Principal Investigator: Dr Amanda Carr, University College London PhD Studentship
Development of 'human stroke-on-a-chip' model to replace rodent stroke models Principal Investigator: Dr Hilary Carswell, University of Strathclyde PhD Studentship
Multi-omic analysis of human poor risk acute myeloid leukaemia to replace xenotransplantation assays and expand leukaemic stem cells Principal Investigator: Dr William Grey, University of York PhD Studentship
Human sensory neuron and macrophage co-culture; developing a model to test agents capable of disrupting painful neuroimmune signalling Principal Investigator: Dr Greg Weir, University of Glasgow PhD Studentship