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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

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Model

51 results

Sharp and to the Point: Developing a device for injections in mice that avoids the re-use of needles

Contractor: Mr Ian Quirk, Active Needle Technology Ltd

CRACK IT Challenge

A white mouse being held by a hand wearing a blue glove

Developing an automated apparatus for continual trials recognition memory in rodents

Contractor: Dr Alex Easton

CRACK IT Solution

An apparatus that includes a testing chamber in which the white mouse can explore objects and includes a holding chamber

Mouse Smart Hoppers (Moshers)

Contractor: Dr Lawrence Moon, Research Devices Ltd

CRACK IT Challenge

Validating CombiDART in the agrochemical sector

Contractor: Professor Alison Woollard

CRACK IT Solution

Two non-vertebrate model systems, the nematode C. elegans and the social amoeba Dictyostelium discoideum to rapidly assess compounds for DART.

DARTpaths: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects

Contractor: Professor Raymond Pieters, University of Applied Sciences Utrecht (UASU)

CRACK IT Challenge

Development and evaluation of the Animal Welfare Assessment Grid (AWAG)

Contractor: Mr Mike Dennis, Public Health England

CRACK IT Solution

Parameter diagram breakdown, procedural is greater then psychological

RespiraTox: In silico model for predicting human respiratory irritation

Contractor: Dr Sylvia Escher, Fraunhofer ITEM

CRACK IT Challenge

Validating the cross-species comparative in silico platform (CRISP)

Contractor: Dr Will Krawszik

CRACK IT Solution

3D hiPSC derived laminated retinal model as a tool for toxicology studies

Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd

CRACK IT Challenge

Microfluidic Automated Platform for Osteoarthritis Drug Screening (MA-PODS)

Contractor: Professor Anne Dickinson, Alcyomics Ltd

CRACK IT Challenge

X-ray graphic of legs, the right leg has joint pain

Neuroinflammation and nociception in a dish

Contractor: Professor Adalberto Merighi

CRACK IT Solution

Neuroinflammation and nociception in a dish

Non-invasive in vivo tissue imaging with functional optical coherence tomography (OCT)

Contractor: University of Washington

CRACK IT Solution

Four 3D structual images of tissue of tissue imaging with functional optical coherence tomography

Design, Fabrication and Testing of a Mouse Embryo Culture Chip

Contractor: Dr Virginia Pensabene, University of Leeds

CRACK IT Challenge

Integrated web platform for agro-chemical formulation toxicity classification and data sharing

Contractor: Professor Jonathan Timmis, SimOmics Ltd

CRACK IT Challenge

Using chicken eggs to advance the 3Rs in cancer drug discovery

Contractor: Dr Jean Viallet

CRACK IT Solution

Injecting a chicken egg under a spotlight

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Demuris)

Contractor: Dr Olivia Champion

CRACK IT Solution

Galleria mellonella larvaes in a green tub

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Envigo)

Contractor: Dr Olivia Champion

CRACK IT Solution

3D hiPSC derived skin model and in-silico skin modelling of metabolism

Contractor: Newcells Biotech Ltd

CRACK IT Challenge

A human IPS cell model for gene therapy vector safety evaluation

Contractor: GeneWerk GmbH

CRACK IT Challenge

Comprehensive target screening by label-free cell microarray profiling to reduce animal efficacy and toxicology studies in drug discovery

Contractor: Dr James Sidaway

CRACK IT Solution

Four stages of target screening by label-free cell microarray profiling