Search our portfolio

Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

60 results

T-ALERT: Developing an in vitro assay to evaluate the tumourigenicity of human engineered T cell therapies

Contractor: Professor Toni Cathomen, University of Freiburg

CRACK IT Challenge

Thyroid Tox: Developing a QSAR and molecular docking tool to predict thyroid receptor-mediated human endocrine disruption

Contractor: Dr Paul Thomas, KREATiS

CRACK IT Challenge

Thyroid Tox Challenge image of molecules

Virtual Second Species: Applying advanced computational and mathematical modelling approaches to develop a suite of virtual dog tissues and organs to model toxicological endpoints for new chemical entities

Contractor: Dr Stephan Schaller, esqLABS GmbH

CRACK IT Challenge

Virtual Second Species Challenge image of abstract network on a blue background

SAFE: Developing a suite of innovative bioassays to replace in vivo fish studies in chemical safety screening and regulatory environmental risk assessment.

Contractor: Dr Stephan Fischer, aQuaTox-Solutions GmbH

CRACK IT Challenge

STRATIS: A human-relevant in vitro or ex vivo platform that recapitulates the complex structures of skeletal muscle and the pathology of significant injury to them.

Contractor: Professor Mark Lewis, Loughborough University

CRACK IT Challenge

Animal-free in vitro: Adapting established Organisation for Economic Development Test Guideline in vitro assays so that they are free from animal-derived products

Contractor: Dr Victoria Hutter, ImmuOne Ltd

CRACK IT Challenge

Animal free in vitro Challenge image of test tubes

In vitro TDAR: Developing a human in vitro T-cell dependent antibody response (TDAR) assay to assess immune enhancement

Contractor: Dr Karla Queiroz, Mimetas B.V.

CRACK IT Challenge

Challenge 35 in vitro TDAR image of antibodies

MouseMApp: An application to monitor the welfare of mice

Contractor: Dr Matt Leach, Newcastle University

CRACK IT Challenge

MouseMAPP Challenge image of a mouse in a pair of hands

Tat-Fit: Developing a method that allows tamoxifen to be added to rodent chow without changing its palatability or consumption by the animals

Contractor: Dr Fang Liu, Fluid Pharma Ltd

CRACK IT Challenge

Tat fit Challenge image of mouse in cage

Sharp and to the Point: Developing a device for injections in mice that avoids the re-use of needles

Contractor: Mr Ian Quirk, Active Needle Technology Ltd

CRACK IT Challenge

A white mouse being held by a hand wearing a blue glove

CleanCut: Developing a human in vitro model to assess the safety of gene edited human haemopoietic stem cells

Contractor: Dr Alessandro Rotilio, MOAB srl

CRACK IT Challenge

Developing an automated apparatus for continual trials recognition memory in rodents

Contractor: Dr Alex Easton, Durham University

CRACK IT Solution

An apparatus that includes a testing chamber in which the white mouse can explore objects and includes a holding chamber

Moshers: Mouse Smart Hoppers

Contractor: Dr Lawrence Moon, Research Devices Ltd

CRACK IT Challenge

Validating CombiDART in the agrochemical sector

Contractor: Professor Alison Woollard, University of Oxford

CRACK IT Solution

Two non-vertebrate model systems, the nematode C. elegans and the social amoeba Dictyostelium discoideum to rapidly assess compounds for DART.

ImmuLiver – An immunologically-competent in vitro model of the human liver for the assessment of Yellow Fever vaccine attenuation

Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd

CRACK IT Challenge

RaTS - Developing a device for objective monitoring of rheumatoid arthritis progression in rodents

Contractor: Associate Professor Martin Hedegaard, University of South Denmark (SDU)

CRACK IT Challenge

X-ray of left and right hand showing joint inflammation from Rheumatoid arthritis

DARTpaths: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects

Contractor: Professor Raymond Pieters, University of Applied Sciences Utrecht (UASU)

CRACK IT Challenge

A new sensor platform combining plastic antibodies with simple thermal detection

Contractor: Dr Marloes Peeters, Manchester Metropolitan University

CRACK IT Solution

Sensor platform combining plastic antibodies with simple thermal detection

Development and evaluation of the Animal Welfare Assessment Grid (AWAG)

Contractor: Mr Mike Dennis, Public Health England

CRACK IT Solution

Parameter diagram breakdown, procedural is greater then psychological

RespiraTox: In silico model for predicting human respiratory irritation

Contractor: Dr Sylvia Escher, Fraunhofer ITEM

CRACK IT Challenge