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51 results

Sharp and to the Point: Developing a device for injections in mice that avoids the re-use of needles

Contractor: Mr Ian Quirk, Active Needle Technology Ltd,

CRACK IT Challenge

A white mouse being held by a hand wearing a blue glove

Developing an automated apparatus for continual trials recognition memory in rodents

Contractor: Dr Alex Easton,

CRACK IT Solution

An apparatus that includes a testing chamber in which the white mouse can explore objects and includes a holding chamber

Moshers: Mouse Smart Hoppers

Contractor: Dr Lawrence Moon, Research Devices Ltd,

CRACK IT Challenge

Validating CombiDART in the agrochemical sector

Contractor: Professor Alison Woollard,

CRACK IT Solution

Two non-vertebrate model systems, the nematode C. elegans and the social amoeba Dictyostelium discoideum to rapidly assess compounds for DART.

DARTpaths: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects

Contractor: Professor Raymond Pieters, University of Applied Sciences Utrecht (UASU),

CRACK IT Challenge

Development and evaluation of the Animal Welfare Assessment Grid (AWAG)

Contractor: Mr Mike Dennis, Public Health England,

CRACK IT Solution

Parameter diagram breakdown, procedural is greater then psychological

RespiraTox: In silico model for predicting human respiratory irritation

Contractor: Dr Sylvia Escher, Fraunhofer ITEM,

CRACK IT Challenge

Validating the cross-species comparative in silico platform (CRISP)

Contractor: Dr Will Krawszik,

CRACK IT Solution

Retinal 3D: 3D hiPSC derived laminated retinal model as a tool for toxicology studies

Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd,

CRACK IT Challenge

Osteo-chip: Microfluidic Automated Platform for Osteoarthritis Drug Screening (MA-PODS)

Contractor: Professor Anne Dickinson, Alcyomics Ltd,

CRACK IT Challenge

X-ray graphic of legs, the right leg has joint pain

Non-invasive in vivo tissue imaging with functional optical coherence tomography (OCT)

Contractor: University of Washington,

CRACK IT Solution

Four 3D structual images of tissue of tissue imaging with functional optical coherence tomography

Maximise: Integrated web platform for agro-chemical formulation toxicity classification and data sharing

Contractor: Professor Jonathan Timmis, SimOmics Ltd,

CRACK IT Challenge

Neuroinflammation and nociception in a dish

Contractor: Professor Adalberto Merighi,

CRACK IT Solution

Neuroinflammation and nociception in a dish

EASE: Design, Fabrication and Testing of a Mouse Embryo Culture Chip

Contractor: Dr Virginia Pensabene, University of Leeds,

CRACK IT Challenge

Using chicken eggs to advance the 3Rs in cancer drug discovery

Contractor: Dr Jean Viallet,

CRACK IT Solution

Injecting a chicken egg under a spotlight

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Demuris)

Contractor: Dr Olivia Champion,

CRACK IT Solution

Galleria mellonella larvaes in a green tub

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Envigo)

Contractor: Dr Olivia Champion,

CRACK IT Solution

Metaboderm: 3D hiPSC derived skin model and in-silico skin modelling of metabolism

Contractor: Newcells Biotech Ltd,

CRACK IT Challenge

InMutaGene: A human IPS cell model for gene therapy vector safety evaluation

Contractor: GeneWerk GmbH,

CRACK IT Challenge

Comprehensive target screening by label-free cell microarray profiling to reduce animal efficacy and toxicology studies in drug discovery

Contractor: Dr James Sidaway,

CRACK IT Solution

Four stages of target screening by label-free cell microarray profiling