A novel product for reducing animal numbers in the production of transgenic mice Contractor: Dr Nadia Gopichandran, Ostara Biomedical Ltd CRACK IT Solution
QSARs Mix: Development of high accuracy QSARs for mixtures to bridge the data gaps in skin and eye irritation Contractor: Dr Paul Thomas, KREATiS CRACK IT Challenge
DRGNET: Developing an ethical, sustainable, human sensory neuron culture model for use in therapeutic pain research Contractor: Professor Andrew Hart, NHS Greater Glasgow & Clyde CRACK IT Challenge
NephroTube: toxicity screening with a human renal cell line in a perfused titerplate Contractor: Northwestern Switzerland CRACK IT Challenge
VIDR: A multiscale model to minimise animal usage in Leishmaniasis drug development Contractor: Professor Paul Kaye, University of York CRACK IT Challenge
UnTangle: A microfluidics based drug-screening platform for human tau mutation neurons Contractor: Dr Selina Wray, University College London CRACK IT Challenge
InPulse: Engineered 2D & 3D hiPSC-CM platforms to detect cardiovascular safety liabilities Contractor: Professor Chris Denning, University of Nottingham CRACK IT Challenge
State of the art in vitro models which accurately predict human liver toxicity Contractor: Dr Dave Hay, University of Edinburgh CRACK IT Solution
Non-invasive diffusion tracking in pharmacokinetics Contractor: Dr Dan Daly, Lein Applied Diagnostics CRACK IT Solution
Reducing animal numbers in tasks of memory Contractor: Dr Alex Easton, University of Durham CRACK IT Solution
Using human pluripotent stem cell-derived cardiomyocytes to test drug cardiac toxicity Contractor: Dr Tamer Mohammed, University of Manchester CRACK IT Solution
Rodent Little Brother: A Brave New Homecage Contractor: Professor Douglas Armstrong, Actual Analytics Ltd CRACK IT Challenge
An early screen for emetic liability of NCEs using the amoeba Dictyostelium Contractor: Professor Robin Williams, Royal Holloway CRACK IT Solution
PREDART: An integrative Dictyostelium, C. elegans and zebrafish approach to assess DART Contractor: Professor Raymond Peters, University of Utrecht CRACK IT Challenge
RETINAS: Origin retinas syringe insertion device Contractor: Allen Pearson, Origin Product Design Limited CRACK IT Challenge
Cognition: A miniature wireless EEG system for continuous monitoring of mice brainwave activity Contractor: Professor Esther Rodriguez-Villegas, Imperial College London CRACK IT Challenge
Rodent Big Brother: The Trurat Show Contractor: Professor Douglas Armstrong, Actual Analytics Ltd CRACK IT Challenge
Cytokines: Improving the predictive capacity of in vitro cytokine release assays to reduce animal use and drug attrition Contractor: Professor Martin Glennie, University of Southampton CRACK IT Challenge
IVIVE: Development and mathematical modelling of zonated hollow fibre bioreactors for in vitro to in vivo extrapolation of systemic chemical toxicity Contractor: Dr Dominic Williams, University of Liverpool CRACK IT Challenge
BADIPS: The development of cell lines relevant for the discovery of new treatments for bipolar affective disorder Contractor: Professor Andrew McIntosh, University of Edinburgh CRACK IT Challenge