3D bio-printing human pluripotent stem cell-derived skeletal muscle constructs for disease modelling and drug discovery Principal Investigator: Dr Yung-Yao Lin, Queen Mary University of London PhD Studentship
Development of non-mammalian, preclinical screening tools for the predictive analysis of cardiotoxicity Principal Investigator: Dr Grant Wheeler, University of East Anglia PhD Studentship
Developing an in silico, spectroscopic imaging toolkit for assessing skin penetration Principal Investigator: Dr Tao Chen, University of Surrey PhD Studentship
A 3Rs approach to assess drug toxicity on the mammalian embryo during early pregnancy in vitro Principal Investigator: Dr David Turner, University of Liverpool PhD Studentship
Ex vivo drug screening using human tissue to personalise cancer therapy and replace murine avatars Principal Investigator: Dr Spencer Collis, University of Sheffield PhD Studentship
A living biobank of post-surgical residual glioblastoma to replace animal studies Principal Investigator: Dr Spencer Collis, University of Sheffield PhD Studentship
Development of an in vitro model to dissect the mechanism of fungal persistence in the cystic fibrosis lung Principal Investigator: Professor Paul Bowyer, University of Manchester PhD Studentship
MacuSIM: A microfluidic, in vitro model of the outer retina as an experimental platform for macular disease and therapeutic trials Principal Investigator: Dr Savannah Lynn, University of Southampton Fellowship
A novel tool that embeds 3Rs principles in multiple sclerosis research Principal Investigator: Dr Julia Edgar, University of Glasgow PhD Studentship
Validating CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes as tools to assist with toxicity profiling, adverse drug reaction notices and black box warnings Principal Investigator: Professor Chris Denning, University of Nottingham Technologies to Tools grant
A computational framework to investigate the mechanical role of the extracellular matrix in tissue development and disease Principal Investigator: Dr Nargess Khalilgharibi, University College London Fellowship
A novel embryonic zebrafish model to replace mammals in the study of 3-hydroxyacyl CoA dehydratase 1-associated muscle disorders Principal Investigator: Dr Rhiannon Morgan, University of Liverpool Fellowship
Modelling O-GlcNAc transferase intellectual disability syndrome in Drosophila Principal Investigator: Professor Daan van Aalten, University of Dundee PhD Studentship
Engineering Galleria Mellonella as a model for infection, immunity and inflammation Principal Investigator: Dr James Wakefield, University of Exeter Project grant
A novel Drosophila platform to replace the use of mice and zebrafish for the study of ER-mitochondria interactions Principal Investigator: Dr Alessio Vagnoni, King's College London Skills and Knowledge Transfer grant
Developing a chick embryo model to aid in development of personalised therapies for malignant pleural mesothelioma Principal Investigator: Professor Judy Coulson, University of Liverpool Project grant
Focused molecular understanding of hypertrophic cardiomyopathy using CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes Principal Investigator: Dr Diogo Mosqueira, University of Nottingham Fellowship
Development of an invertebrate model of alternating hemiplegia of childhood Principal Investigator: Dr Steven Clapcote, University of Leeds PhD Studentship
Development and characterization of a novel endothelialized in vitro model of human atherothrombosis Principal Investigator: Dr Sarah Jones, Manchester Metropolitan University PhD Studentship
An organotypic model of the bone remodelling process Principal Investigator: Dr Amy Naylor, University of Birmingham PhD Studentship