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Topic

Model

Impact stories

631 results

Towards in vitro oncology trials: drug testing in cultured patient derived tumour organoid cultures

Principal Investigator: Professor Andrew Tutt, King's College London

Project grant

Inter-neuronal variability in human nociceptor electrophysiology: experimentally-driven computational study of response to drugs and channelopathies

Principal Investigator: Dr Oliver Britton, University of Oxford

Project grant

Unravelling the mechanism of transcellular chaperone signalling in C. elegans

Principal Investigator: Dr Patricija van Oosten-Hawle, University of Leeds

Project grant

Using chicken eggs to advance the 3Rs in cancer drug discovery

Contractor: Dr Jean Viallet

CRACK IT Solution

Injecting a chicken egg under a spotlight

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Demuris)

Contractor: Dr Olivia Champion, Biosystems Technology

CRACK IT Solution

Galleria mellonella larvaes in a green tub

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Envigo)

Contractor: Dr Olivia Champion, Biosystems Technology

CRACK IT Solution

Human tissue models for lung disease

Principal Investigator: Professor Maria Belvisi, Imperial College London

Infrastructure grant

Developing a zebrafish model of neurovascular coupling (NVC)

Principal Investigator: Dr Clare Howarth, University of Sheffield

Project grant

Developing alternative models to evaluate the impact of nanomaterials on neutrophils during the stimulation and resolution of inflammation

Principal Investigator: Dr Helinor Johnston, Heriot-Watt University

Project grant

Cas9 mediated in vitro gene editing in primary mammary epithelial cells

Principal Investigator: Dr Walid Khaled, University of Cambridge

PhD Studentship

Reducing animal use in thrombosis research with an ex vivo injury model

Principal Investigator: Dr Matthew Harper, University of Cambridge

PhD Studentship

Developing an Organ on a Chip Model to Test the Therapeutic Efficacy of Adhirons in Breast Cancer

Principal Investigator: Dr Darren Tomlinson, University of Leeds

PhD Studentship

Development of functional 3D human intestinal mucosae to replace rodent models and improve the predictive accuracy of existing in vitro systems

Principal Investigator: Professor Stefan Przyborski, Durham University

PhD Studentship

Developing a Drosophila melanogaster model of the cardiac myocyte action potential to investigate function and performance

Principal Investigator: Dr Jeremy Niven, University of Sussex

PhD Studentship

Reducing animal usage in antifungal drug development: iRFP reporter strains and imaging infection

Principal Investigator: Dr Donna MacCallum, University of Aberdeen

PhD Studentship

Developing Human Glioma OrganDot Cultures

Principal Investigator: Professor William Gray, Cardiff University

PhD Studentship

Refining an in vitro system of predictive biomarkers of in vivo liposome efficacy

Principal Investigator: Dr Andrew Devitt, Aston University

PhD Studentship

Refinement of hematopoietic cell transplantation using optical imaging in zebrafish

Principal Investigator: Professor Margaret Dallman, Imperial College London

PhD Studentship

Using zebrafish for pre-clinical brain haemorrhage research

Principal Investigator: Professor Stuart Allan, University of Manchester

PhD Studentship

Reducing the use and refining the distribution of male Xenopus

Principal Investigator: Professor Matthew Guille, University of Portsmouth

Infrastructure grant