Molecularly Imprinted Nanoparticles (MIP NPs) as non-animal antibodies substitutes for detection of viruses Principal Investigator: Dr Alessandro Poma, University College London Fellowship
Development of a patient derived cellular model of circadian disruption in bipolar disorder Principal Investigator: Dr Sridhar Vasudevan, University of Oxford PhD Studentship
QSARs Mix: Development of high accuracy QSARs for mixtures to bridge the data gaps in skin and eye irritation Contractor: Dr Paul Thomas, KREATiS, CRACK IT Challenge
Contribution of autophagy to the maintenance, invasion and metastasis of melanoma stem-like sub populations. Principal Investigator: Dr David Hill, Newcastle University Fellowship
Find the target of valproic acid: pioneering the use of a non-animal model for basic biomedical (epilepsy) research Principal Investigator: Professor Robin Williams, Royal Holloway University of London PhD Studentship
Developing microfluidic systems for high throughput studies of functional neuronal networks Principal Investigator: Dr Michele Zagnoni, University of Strathclyde PhD Studentship
Reduction of use of experimental mice in type 1 diabetes research through non-invasive, in vivo longitudinal imaging Principal Investigator: Dr Maja Wallberg, University of Cambridge Project grant
DRGNET: Developing an ethical, sustainable, human sensory neuron culture model for use in therapeutic pain research Contractor: Professor Andrew Hart, NHS Greater Glasgow & Clyde, CRACK IT Challenge
Labelled IMS TAG Proteins for Quantitative Mass Spectrometry Imaging Principal Investigator: Professor Malcolm Clench, Sheffield Hallam University Strategic grant
Generating zebrafish models of human eye movement disorders to replace mouse models Principal Investigator: Dr Ivana Poparic, King's College London Fellowship
Creating an in vitro model of pathogenic ossification to explore methods for dispersion Principal Investigator: Professor Liam Grover, University of Birmingham PhD Studentship
NephroTube: toxicity screening with a human renal cell line in a perfused titerplate Contractor: Northwestern Switzerland, CRACK IT Challenge
VIDR: A multiscale model to minimise animal usage in Leishmaniasis drug development Contractor: Professor Paul Kaye, University of York, CRACK IT Challenge
UnTangle: A microfluidics based drug-screening platform for human tau mutation neurons Contractor: Dr Selina Wray, University College London, CRACK IT Challenge
InPulse: Engineered 2D & 3D hiPSC-CM platforms to detect cardiovascular safety liabilities Contractor: Professor Chris Denning, University of Nottingham, CRACK IT Challenge
Replacing rodent models for investigating the influence of the microbiome upon innate immune responses and resistance to pathogens Principal Investigator: Dr Rachel Lawrence, Royal Veterinary College PhD Studentship
A 3D air-liquid interface airway epithelial cell model to study pathogen interactions within the bovine respiratory tract Principal Investigator: Dr Robert Davies, University of Glasgow Project grant
SEARCHbreast: A virtual resource to facilitate sharing breast cancer materials and knowledge to benefit the 3Rs Principal Investigator: Professor Valerie Speirs, University of Leeds Infrastructure grant
EFucci an atlas of proliferation to reduce mouse usage in embryonic proliferation assays Principal Investigator: Dr Richard Mort, MRC Human Genetics Unit University of Edinburgh Pilot study grant
Towards an in vitro system of predictive biomarkers of in vivo liposome efficacy Principal Investigator: Dr Andrew Devitt, Aston University Pilot study grant