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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

11 results

Review of the value of urinalysis assessments in toxicity studies

Current contact: Dr Fiona Sewell,

Office-led project

Assessing the resource and animal use implications of new EU REACH endocrine disruptor assessment information requirements

Current contact: Dr Natalie Burden,

Office-led project

Re-evaluating the need for mAb chronic toxicity studies

Current contact: Dr Fiona Sewell,

Office-led project

Fig. 5. Integrated weight-of-evidence model modified from Chien et al. 2023

Applying exposure science to increase the utility of non-animal data in efficacy and safety testing

Current contact: Dr Natalie Burden,

Office-led project

Adoption of the Fixed Concentration Procedure for acute inhalation studies

Current contact: Dr Fiona Sewell,

Office-led project

Applying pathways-based approaches across the biosciences

Current contact: Dr Natalie Burden,

Office-led project

Pharmacokinetics in candidate selection

Current contact: Dr Fiona Sewell,

Office-led project

Reducing the use of recovery animals

Current contact: Dr Fiona Sewell,

Office-led project

Reducing animal use in monoclonal antibody development

Current contact: Dr Fiona Sewell,

Office-led project

Refining MTD studies

Current contact: Dr Fiona Sewell,

Office-led project

Single dose acute toxicity studies

Current contact: Dr Fiona Sewell,

Office-led project