Multi-laboratory validation of a new animal product-free test guideline addition for the in vitro micronucleus test Principal Investigator: Professor Victoria Hutter, University of Hertfordshire Strategic grant
Validation of Scinora serum-free media formulations and Xplace supplement for the development of animal-free NAMs for nanotoxicology Principal Investigator: Dr Fiona Murphy, University of Strathclyde Strategic grant
Establishing a human lymphoid organoid and explant hub to replace animal models in immunology research Principal Investigator: Dr Pablo Céspedes, University of Oxford Strategic grant
Upscaling human stem cell assays to detect autoantibodies in central nervous system diseases Principal Investigator: Dr Lahiru Handunnetthi, University of Oxford Strategic grant
Development of a fully humanised model for understanding platelet function Principal Investigator: Dr Alice Pollitt, University of Reading Project grant
Supporting 3Rs approaches in biologicals testing Current contact: Dr Elliot Lilley Office-led project
A human ex vivo model of haemostasis: A replacement for rodent tail bleeding assays Principal Investigator: Dr Sarah Jones, Manchester Metropolitan University Project grant
RoboHog: developing an in vitro gut model system of the porcine hindgut Principal Investigator: Dr Anthony Buckley, University of Leeds Project grant
A novel in silico framework for early mammalian embryo development Principal Investigator: Dr David Richards, University of Exeter Project grant
Understanding mechanisms driving lung disease caused by environmental particulate matter Principal Investigator: Dr Nicholas Hannan, University of Nottingham Project grant
Modulating Macrophage Phenotypes During Infection In Zebrafish Principal Investigator: Dr Phillip Elks, University of Sheffield PhD Studentship
A 3Rs platform for glial research: From animal to human to in-silico models Principal Investigator: Professor Dmitri Rusakov, University College London Project grant
High fidelity computational approaches to exploit new structures of cardiac ion channels Principal Investigator: Dr Andrew Leach, University of Manchester PhD Studentship
Modelling of thrombus dynamics in a microfluidic 'vasculature' Principal Investigator: Dr Nicola Mutch, University of Aberdeen PhD Studentship
3D patient-derived organoids: A viable and complementary model to study neural system dysfunction in Alzheimer's Disease Principal Investigator: Dr Marc Busche, University College London PhD Studentship
Understanding how altered brain metabolism causes mitochondrial disease Principal Investigator: Dr Joseph Bateman, King's College London PhD Studentship
Understanding brain regeneration in a zebrafish larval model of intracerebral haemorrhage Principal Investigator: Dr Siobhan Crilly, University of Manchester Fellowship
Use of induced pluripotent stem cell derived cardiomyocytes to test the consequences of genetic variants in atrial and ventricular arrhythmias Principal Investigator: Dr Katja Gehmlich, University of Birmingham PhD Studentship
Focused molecular understanding of hypertrophic cardiomyopathy using CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes Principal Investigator: Dr Diogo Mosqueira, University of Nottingham Fellowship
Development and characterization of a novel endothelialized in vitro model of human atherothrombosis Principal Investigator: Dr Sarah Jones, Manchester Metropolitan University PhD Studentship