Fusogenic liposomes: the innovative delivery of compounds into human platelets to reduce animal use in platelet research Principal Investigator: Dr Alice Pollitt, University of Reading PhD Studentship
Fully humanised 3D vascular perfused model for breast cancer modelling and therapeutic screening Principal Investigator: Professor Valerie Speirs, University of Aberdeen Partnerships and impact awards
Transfer of the epicardial-cardiac organotypic culture model to support the ex vivo screening of gene therapy candidates Principal Investigator: Dr Paola Campagnolo, University of Surrey Partnerships and impact awards
Replacing the need for patient-derived xenografts and matrigel organoid culture as preclinical models for breast cancer Principal Investigator: Dr Robert Clarke, The University of Manchester Partnerships and impact awards
Using zebrafish embryos to identify genes that protect against atherosclerosis Principal Investigator: Professor Paul Evans, University of Sheffield PhD Studentship
Recreating thrombosis models using tissue-engineered arterial constructs: A novel method to reduce and replace mice used in platelet research Principal Investigator: Dr Alan Harper, Keele University PhD Studentship
Ex vivo model for the study of epicardium-targeted therapies Principal Investigator: Dr Paola Campagnolo, University of Surrey Project grant
Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts Principal Investigator: Dr Anna Grabowska, University of Nottingham PhD Studentship
A 3D in vitro glioblastoma cell culture system for identification and evaluation of novel radiosensitisers reducing rodent xenograft studies Principal Investigator: Professor Anthony Chalmers, University of Glasgow Project grant
Developing a zebrafish model of neurovascular coupling (NVC) Principal Investigator: Dr Clare Howarth, University of Sheffield Project grant
Using zebrafish for pre-clinical brain haemorrhage research Principal Investigator: Professor Stuart Allan, University of Manchester PhD Studentship
A multi-cellular 3D model of human breast tissue to replace rodent xenograft models in breast cancer research Principal Investigator: Professor Cathy Merry, University of Nottingham Project grant
An organotypic model of bronchial dysplasia Principal Investigator: Dr Frank McCaughan, University of Cambridge PhD Studentship
Development of a tetanus-sensitive cell line for assaying tetanus toxin activity Principal Investigator: Professor Bazbek Davletov, University of Sheffield Project grant
A disease model to investigate vascular endothelial function for genetic stroke CADASIL Principal Investigator: Dr Tao Wang, University of Manchester PhD Studentship
Carotid artery endothelial growth: a novel in vitro assay Principal Investigator: Dr Atticus Hainsworth, St George's University of London Project grant
An ex vivo mouse mandible culture model to study inflammatory bone disease Principal Investigator: Professor Alastair Sloan, Cardiff University Project grant