Search our portfolio

Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

Impact stories

425 results

Development of an in vitro model for the anterior region of the eye

Principal Investigator: Dr Nigel Fullwood, Lancaster University

Project grant

A stock image of round glass dishes containing blue and green liquid arranged closely together.

Development of a new human cell genotoxicity assay to reduce the use of live animals in drug development

Principal Investigator: Professor Richard Walmsley, University of Manchester

Project grant

Embryonic stem cell-derived cardiomyocytes as a model system for cardiac investigations

Principal Investigator: Professor Sian Harding, Imperial College London

Project grant

Development of an air-interface in vitro organ culture model (IVOC) of bovine respiratory epithelium

Principal Investigator: Dr Alexander Tucker, University of Cambridge

Project grant

a photo showing a glass slide being held by a scientist, near to a microscope

Development of replacement in vitro assays for the quantification of clostridial vaccine antigens

Principal Investigator: Dr Keith Redhead

Project grant

Long range camera shot of Dr Keith Redhead in a laboratory

The development of a cell-based diabetic wound bioassay

Principal Investigator: Professor David Thomas, Cardiff University

Project grant

Replacement of the mouse bioassay: Development of SPE and LC-MS for detection of paralytic shellfish poisoning toxins

Principal Investigator: Dr Elizabeth Turrell, Marine Scotland Science

Project grant

Maintenance of Lutzomyia longipalpis colonies using an artificial membrane blood-feeding method

Principal Investigator: Professor Richard Ward, Keele University

Project grant

Cell lines for prediction of drug metabolism and toxicity in man

Principal Investigator: Professor Charles Wolf, Dundee Technopol CXR Biosciences Ltd

Project grant

Supporting the adoption of microphysiological systems for COVID research

Current contact: Dr Anthony Holmes

Office-led project

Organ on a chip microphysiological system

Human Tissue for Safety Pharmacology

Current contact: Dr Anthony Holmes

Office-led project

Cell culture plate being removed from an incubator

Improving the predictive power of models for cancer research

Current contact: Dr Anthony Holmes

Office-led project

Microscope image of cells glowing purple

Applying exposure science to increase the utility of non-animal data in efficacy and safety testing

Current contact: Dr Natalie Burden

Office-led project

Opportunities to apply the 3Rs in the safety assessment of nanomaterials

Current contact: Dr Natalie Burden

Office-led project

Utilising QSARs to predict fish acute toxicity of pesticide metabolites

Current contact: Dr Natalie Burden

Office-led project

Advancing the development and application of non-animal technologies (NATs)

Current contact: Dr Anthony Holmes

Office-led project

A collection of test tubes containing coloured liquid

Engineering tissue alternatives to animals

Current contact: Dr Anthony Holmes

Office-led project

Researcher holding a tissue engineered model

Reducing animal use in complex systems: using nausea and vomiting as a test case

Current contact: Dr Anthony Holmes

Office-led project

Microscope view of Dictyostelium slime mold

Applying pathways-based approaches across the biosciences

Current contact: Dr Natalie Burden

Office-led project

Redundancy in the acute toxicity testing of chemicals

Current contact: Dr Natalie Burden

Office-led project