Virtual Second Species: Applying advanced computational and mathematical modelling approaches to develop a suite of virtual dog tissues and organs to model toxicological endpoints for new chemical entities Contractor: Dr Stephan Schaller, esqLABS GmbH CRACK IT Challenge
A novel approach for modelling the healthy nose-brain axis in vitro Principal Investigator: Professor Róisín Owens, University of Cambridge Project grant
A high-throughput spheroid fusion platform for the templated-assembly of 3D neuromuscular junctions Principal Investigator: Dr Fabrice Gielen, University of Exeter Project grant
A human ex vivo model of haemostasis: A replacement for rodent tail bleeding assays Principal Investigator: Dr Sarah Jones, Manchester Metropolitan University Project grant
Human organoid model to generate mucosal immune cell populations Principal Investigator: Dr Joana Neves, King's College London Project grant
Engineering circadian biology into induced pluripotent stem cell organ-on-a-chip models Principal Investigator: Professor David Lee, Queen Mary University of London Project grant
Establishment of a cryo-bank of lineage-committed neural progenitor cells produced from engineered human pluripotent stem cells Principal Investigator: Professor Tilo Kunath, University of Edinburgh Project grant
Advanced human pluripotent stem cell kidney organoid model for investigating development and disease Principal Investigator: Professor Sue Kimber, University of Manchester Project grant
Organ-on-a-chip model of pulmonary arterial cell-cell interactions Principal Investigator: Dr Beata Wojciak-Stothard, Imperial College London Project grant
Implementing an MEA platform in human neurones for studying age-related neural network dysfunction and testing dietary interventions Principal Investigator: Dr Robert Williams, University of Bath Project grant
Epithelial barrier model: in silico modelling and high throughput assessment Principal Investigator: Dr Malgorzata Wiench, University of Birmingham Project grant
Optimising human stem cell models to decipher signals and responses during organogenesis Principal Investigator: Professor Jennifer Nichols, University of Edinburgh Project grant
Mapping mitochondrial contact sites during neuronal ageing and neurodegeneration in Drosophila Principal Investigator: Dr Alessio Vagnoni, King's College London PhD Studentship
Development of novel tools to assay haematopoietic stem cell activity ex vivo Principal Investigator: Professor Marella de Bruijn, University of Oxford PhD Studentship
RoboHog: developing an in vitro gut model system of the porcine hindgut Principal Investigator: Dr Anthony Buckley, University of Leeds Project grant
Developing a lung organoid signalome for real-time analysis of senescence-associated cellular cross talk Principal Investigator: Dr Alison John, Imperial College London Project grant
A platform to investigate multi-tissue crosstalk mediated by exercise induced soluble factors released from human skeletal muscle Principal Investigator: Professor Mark Lewis, Loughborough University Project grant
A novel in silico framework for early mammalian embryo development Principal Investigator: Dr David Richards, University of Exeter Project grant
Developing a next generation in vitro 3D immune organoids system for studying vaccine-induced immune response and immune-ageing across the life-course Principal Investigator: Dr Qibo Zhang, University of Surrey Project grant
Understanding mechanisms driving lung disease caused by environmental particulate matter Principal Investigator: Dr Nicholas Hannan, University of Nottingham Project grant