Human stem cell models of de novo tumorigenesis to replace the use of animals for the study of cancer initiation Principal Investigator: Dr Cinzia Allegrucci, University of Nottingham PhD Studentship
Defining drug delivery into and across the oral mucosa using a tissue engineering and mathematical modelling approach Principal Investigator: Professor Craig Murdoch, University of Sheffield Project grant
Reducing and replacing the animal cost of functional genetics in African trypanosomiasis Principal Investigator: Dr Catarina Gadelha, University of Nottingham Project grant
Validation of an in vitro humanised 3D haematopoietic system to investigate haematological malignancies Principal Investigator: Professor Helen Wheadon, University of Glasgow Project grant
Establishing Drosophila melanogaster as part of the pre-clinical pipeline for anti-metastatic cancer drug discovery Principal Investigator: Dr Kyra Campbell, University of Sheffield Project grant
Transfer of an in vitro model for the evaluation of anticoccidial compounds Principal Investigator: Dr Virginia Marugan-Hernandez, Royal Veterinary College Skills and Knowledge Transfer grant
Replacement of animal use in measuring cardiomyocyte response to drug safety profiling using a novel NMR metabolomics technology Principal Investigator: Dr Rachel Oldershaw, University of Liverpool PhD Studentship
Targeted protein degradation as a novel approach to study protein function in human platelets Principal Investigator: Professor Ingeborg Hers, University of Bristol PhD Studentship
A novel in vitro reporter system for blood stem cell activity Principal Investigator: Dr David Kent, University of York PhD Studentship
Understanding how altered brain metabolism causes mitochondrial disease Principal Investigator: Dr Joseph Bateman, King's College London PhD Studentship
Combining a fully synthetic hydrogel with human intestinal organoids to model pathological matrix remodelling in Inflammatory Bowel Disease Principal Investigator: Professor Eileen Gentleman, King's College London PhD Studentship
3D bioprinted microtissues to develop patient-specific non-animal technologies (NAT) in cancer drug development Principal Investigator: Dr Deepali Pal, Northumbria University PhD Studentship
Insects as models to study wound healing, infection and the wound microbiome Principal Investigator: Dr Ronan McCarthy, Brunel University PhD Studentship
A 3Rs approach to investigate the feto-maternal interface: visualisation of pathogen and antibody in a 3D in vitro human placental model Principal Investigator: Professor Aras Kadioglu, University of Liverpool PhD Studentship
Development and validation of 3D in vitro dormant myeloma cell models to reduce and replace animal studies Principal Investigator: Dr Michelle Lawson, University of Sheffield PhD Studentship
Development of a New Human Model of Lung Squamous Cell Carcinoma Progression Principal Investigator: Dr Carlos Lopez-Garcia, University of Manchester Project grant
Establishing the novel ex-vivo focal demyelination model of Multiple Sclerosis in other laboratories to reduce and replace live animal use Principal Investigator: Dr Ben Newland, Cardiff University Skills and Knowledge Transfer grant
A novel Drosophila model of chronic inflammatory lung disease to explore airway damage, inflammation and infection in vivo Principal Investigator: Dr Helen Weavers, University of Bristol PhD Studentship
Determining the efficacy and safety of cancer chemotherapeutics for cholangiocarcinoma (CCA) using Human Precision Cut Tissue Slices (hPCTS) Principal Investigator: Dr Laura Randle, Unviversity of Liverpool Skills and Knowledge Transfer grant
Go North: Expanding the use of the chick embryo model in cancer research to a multiuser facility at the University of Strathclyde Principal Investigator: Dr Marie Boyd, University of Strathclyde Skills and Knowledge Transfer grant