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Topic

Model

Impact stories

462 results

SAFE: Developing a suite of innovative bioassays to replace in vivo fish studies in chemical safety screening and regulatory environmental risk assessment.

Contractor: Dr Stephan Fischer, aQuaTox-Solutions GmbH

CRACK IT Challenge

Development of an in vitro system that mimics B and T helper cell responses in porcine lymph nodes

Principal Investigator: Dr Wilhelm Gerner, The Pirbright Institute

Project grant

Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research

Principal Investigator: Dr Marko Nikolić, University College London

PhD Studentship

A high-throughput-compatible animal-cell-free miniaturised thymic organoid model for thymus biology studies and in vitro T cell production

Principal Investigator: Professor Clare Blackburn, University of Edinburgh

Project grant

Production of a Human Growth Plate Organ-Chip Model of Skeletal Development

Principal Investigator: Professor Martin Knight, Queen Mary University of London

Project grant

Photograph of Professor Martin Knight's lab group, from left to right, Dr Joanne Nolan (Centre Scientist, QM+Emulate Organs-on-Chips Centre), Dr Timothy Hopkins (named researcher), Prof. Martin Knight (PI), Dr Angus Wann (Co-I).

In vitro digestibility - reducing animal use whilst meeting the demand to evaluate alternative proteins

Principal Investigator: Professor John Brameld, University of Nottingham

Project grant

A collection of test tubes containing coloured liquid

Developing a complex in vitro airway model to study respiratory viral pathogenesis, lung macrophage function and herpesviral vaccine vectors in pigs

Principal Investigator: Dr Gyorgy Fejer, University of Plymouth

Project grant

Developing a human vascularised pancreatic islet on a chip - VIOC

Principal Investigator: Dr Victoria Salem, Imperial College London

Project grant

Novel in vitro platform to study molecular mechanisms of neurotransmitter release and synaptic plasticity

Principal Investigator: Professor Kirill Volynski, University College London

Project grant

Testing and validation of an in vitro 3D human chondrocyte model to replace animal use in mechanobiology research

Principal Investigator: Dr Emma Blain, Cardiff University

Project grant

Embryonic zebrafish models of HACD1-deficiency to replace mammals in congenital myopathy and lipidomic research

Principal Investigator: Dr Gemma Walmsley, University of Liverpool

PhD Studentship

Investigation of dopamine transporter dysfunction linked to DAT/SLC6A3 mutations in CRISPR-Cas engineered C. elegans and patient derived iPCSs

Principal Investigator: Dr Eva Kevei, University of Reading

PhD Studentship

Modulating Macrophage Phenotypes During Infection In Zebrafish

Principal Investigator: Dr Phillip Elks, University of Sheffield

PhD Studentship

Developing gene editing technologies in the non-mammalian infectious disease model organism, Galleria mellonella

Principal Investigator: Dr James Pearce, University of Exeter

Fellowship

A 3Rs platform for glial research: From animal to human to in-silico models

Principal Investigator: Professor Dmitri Rusakov, University College London

Project grant

High fidelity computational approaches to exploit new structures of cardiac ion channels

Principal Investigator: Dr Andrew Leach, University of Manchester

PhD Studentship

Drosophila based screening to replace mammalian systems to identify the functional role of candidate genes in controlling muscle dyadic architecture

Principal Investigator: Professor Andrew Trafford, University of Manchester

PhD Studentship

Development of endometrial/myometrial organoids to study disorders of pregnancy and parturition

Principal Investigator: Dr Andrew Blanks, University of Warwick

Project grant

Refining in vivo studies of cancer metastasis with next-generation explant-in-chip perfusion models

Principal Investigator: Professor Darryl Overby, Imperial College London

Project grant

Developing a stem-cell prostate organoid model - reducing global animal usage in prostate development and cancer studies

Principal Investigator: Dr Adriana Buskin, Newcastle University

Fellowship