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Impact stories

631 results

Reducing animal dependency in diabetes research through pancreatic stem cells

Principal Investigator: Professor Mark Dunne, University of Manchester

PhD Studentship

Construction of a miniaturised human lymph node model as an alternative to the Local Lymph Node Assay

Principal Investigator: Professor Amir Ghaemmaghami, University of Nottingham

PhD Studentship

Reduction & refinement in animal models of neuropathic pain: using systematic review & meta-analysis

Principal Investigator: Dr Emily Sena, University of Edinburgh

Project grant

Using induced pluripotent stem cells as a replacement for in vivo models to screen novel therapies which target self-renewal pathways in chronic myeloid leukaemia

Principal Investigator: Dr Helen Wheadon, University of Glasgow

PhD Studentship

Refining, reducing and replacing in vivo WHO-standard preclinical assays of snake venom pathology and antivenom efficacy

Principal Investigator: Dr Robert Harrison, Liverpool School of Tropical Medicine

PhD Studentship

A stock image of round glass dishes containing blue and green liquid arranged closely together.

Developing an integrated "in vitro carcinogenicity predictive tool" utilising in vitro cell signalling and cell behaviour assessment coupled with in vitro genotoxicity data

Principal Investigator: Professor Gareth Jenkins, Swansea University

Strategic grant

Wireless high-bandwidth trans-cutaneous signal transmission

Principal Investigator: Professor Stuart Baker, Newcastle University

Project grant

Development of human epithelial cell transformation models for carcinogen screening, employing defined phenotypic endpoints mechanistically representative of rate-limiting events in human carcinogenesis

Principal Investigator: Professor Robert Newbold, Brunel University

Strategic grant

The use of gene expression profiles to predict protective immunity without the need for disease challenge

Principal Investigator: Dr Roland Ashford, Veterinary Laboratories Agency

Pilot study grant

An advanced model for neurodegeneration studies in the fruit fly Drosophila melanogaster

Principal Investigator: Dr Ezio Rosato, University of Leicester

Project grant

Replacement of animal models for tumour biology with a multifunctional microfluidic-based approach

Principal Investigator: Professor John Greenman, University of Hull

Project grant

A fully-automated system for positive reinforcement training of group-housed non-human primates

Principal Investigator: Dr Andrew Jackson, Newcastle University

Pilot study grant

The assessment of pain using facial expressions in laboratory mice, rats, rabbits and macaques

Principal Investigator: Dr Matt Leach, Newcastle University

Project grant

Cognition: A miniature wireless EEG system for continuous monitoring of mice brainwave activity

Contractor: Professor Esther Rodriguez-Villegas, Imperial College London

CRACK IT Challenge

Rodent Big Brother: The Trurat Show

Contractor: Professor Douglas Armstrong, Actual Analytics Ltd

CRACK IT Challenge

Rat with white fur and red eyes sitting in the corner of a cage. Sawdust and shredded tissue can be seen on the cage floor.

Cytokines: Improving the predictive capacity of in vitro cytokine release assays to reduce animal use and drug attrition

Contractor: Professor Martin Glennie, University of Southampton

CRACK IT Challenge

IVIVE: Development and mathematical modelling of zonated hollow fibre bioreactors for in vitro to in vivo extrapolation of systemic chemical toxicity

Contractor: Dr Dominic Williams, University of Liverpool

CRACK IT Challenge

BADIPS: The development of cell lines relevant for the discovery of new treatments for bipolar affective disorder

Contractor: Professor Andrew McIntosh, University of Edinburgh

CRACK IT Challenge

Development of a non-lethal sampling method to monitor immune response and disease progression in salmonid fish

Principal Investigator: Dr Bertrand Collet, Marine Scotland Science

Project grant

Pilot study investigating the use human stem cell derived neurons in toxicity testing

Principal Investigator: Dr Eric Hill, Aston University

Pilot study grant