An improved C. elegans model of Alzheimer's disease to monitor neuronal signalling activity Principal Investigator: Dr Jamie Johnston, University of Leeds PhD Studentship
3D bio-printing human pluripotent stem cell-derived skeletal muscle constructs for disease modelling and drug discovery Principal Investigator: Dr Yung-Yao Lin, Queen Mary University of London PhD Studentship
Development of non-mammalian, preclinical screening tools for the predictive analysis of cardiotoxicity Principal Investigator: Dr Grant Wheeler, University of East Anglia PhD Studentship
Developing an in silico, spectroscopic imaging toolkit for assessing skin penetration Principal Investigator: Dr Tao Chen, University of Surrey PhD Studentship
A 3Rs approach to assess drug toxicity on the mammalian embryo during early pregnancy in vitro Principal Investigator: Dr David Turner, University of Liverpool PhD Studentship
Ex vivo drug screening using human tissue to personalise cancer therapy and replace murine avatars Principal Investigator: Dr Spencer Collis, University of Sheffield PhD Studentship
A living biobank of post-surgical residual glioblastoma to replace animal studies Principal Investigator: Dr Spencer Collis, University of Sheffield PhD Studentship
Towards an open-source, equipment-agnostic framework for automated welfare monitoring in the home cage Principal Investigator: Dr James Brown, University of Lincoln PhD Studentship
Development of an in vitro model to dissect the mechanism of fungal persistence in the cystic fibrosis lung Principal Investigator: Professor Paul Bowyer, University of Manchester PhD Studentship
Refinement: The impact of peri-operative analgesia on neuropharmacological outcomes in rodent models of chronic pain Principal Investigator: Dr Kirsty Bannister, King's College London PhD Studentship
Sharing new non-invasive circadian phenotyping methods Principal Investigator: Professor Stuart Peirson, University of Oxford Skills and Knowledge Transfer grant
Naturally sterile hybrid mice for the production of embryo transfer recipients Principal Investigator: Dr Ben Davies, University of Oxford Skills and Knowledge Transfer grant
Use of induced pluripotent stem cell derived cardiomyocytes to test the consequences of genetic variants in atrial and ventricular arrhythmias Principal Investigator: Dr Katja Gehmlich, University of Birmingham PhD Studentship
WaterR: A tool for better management and monitoring of rodent fluid intake Principal Investigator: Dr Paul Dodson, University of Bristol Skills and Knowledge Transfer grant
MacuSIM: A microfluidic, in vitro model of the outer retina as an experimental platform for macular disease and therapeutic trials Principal Investigator: Dr Savannah Lynn, University of Southampton Fellowship
Modelling radiobiology effects of X-rays in small laboratory animals to develop guidelines for preclinical computed tomography imaging Principal Investigator: Dr Wendy McDougald, University of Edinburgh Fellowship
A novel tool that embeds 3Rs principles in multiple sclerosis research Principal Investigator: Dr Julia Edgar, University of Glasgow PhD Studentship
Refining the lung cancer mouse model through environmental enrichment Principal Investigator: Dr Deborah Caswell, The Francis Crick Institute Fellowship
Sharp and to the Point: Developing a device for injections in mice that avoids the re-use of needles Contractor: Mr Ian Quirk, Active Needle Technology Ltd, CRACK IT Challenge
Validating CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes as tools to assist with toxicity profiling, adverse drug reaction notices and black box warnings Principal Investigator: Professor Chris Denning, University of Nottingham Technologies to Tools grant