Our programme of work at the NC3Rs has led to a number of online resources made available to aid in designing animal experiments and reporting studies in publications.
This presentation was given by Dr Nathalie Percie du Sert at the HPRA/SFI/HRB 3Rs Conference on 17 May 2017. It provides an overview of our experimental design resources.
The 40-minute video covers:
- An overview of the experimental design resources available on the NC3Rs website
- The ARRIVE guidelines: improving the reporting of biomedical research using animals
- The EDA: improving the design of animal experiments
- SyRF: an online platform for performing systematic reviews
To read more about the key elements of a well-designed experiment, see Experimental design/statistics.
The ARRIVE guidelines and an ARRIVE checklist for use when submitting manuscripts are available, for download.
The Experimental Design assistant along with a user guide and video tutorials can be found on the EDA website.
A more detailed overview of the topics covered in the video is given below, with timeframes for each topic.
|An overview of resource tools available:||01:55|
|Background to reproducibility issues:||02:30|
|The ARRIVE guidelines:||06:18|
|The ARRIVE checklist:||07:10|
|Internal validity – randomisation:||07:54|
|Internal validity – blinding:||11:18|
|Internal validity – sample size calculation:||13:58|
|The EDA diagram:||21:00|
|Feedback and advice from the EDA:||25:33|
|Supporting randomisation, blinding and sample size calculation:||27:39|
|EDA website resources:||28:44|
|Using the EDA diagram for communications:||29:09|
|The EDA workflow:||29:45|
|Objectives of the EDA:||31:26|
|Different uses of the EDA:||34:01|
|Systematic reviews of animal research:||36:12|
|The SyRF web app:||38:13|
|An example of how a systematic review has improved internal validity:||39:55|