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NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research

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Use the filters below to narrow down our resources to those relevant to your role, the model you are interested in, or by topic area. Filters are best used by combining two or more to narrow down the results.

170 results

Posters and other resources on the use of grimace scales to assess pain in laboratory animals.

The mouse, rat and rabbit grimace scale posters layered over each other.

Details of the Rabbit Grimace Scale, including a poster for display in laboratory rooms and corridors.

Screenshot of the top third of the rabbit grimace scale poster showing the orbital tightening facial action units

Guidance, information and recommendations for those working with zebrafish.


Techniques for blood sampling in laboratory animal species to ensure the most appropriate technique is chosen.

Five needles with empty syringes on a pale blue background

Information on techniques for sampling blood in the rat, covering non-surgical, surgical and terminal techniques.

A brown and white rat in a cage, with an icon of a needle and syringe on a yellow background in the corner of the image.

Guidance on non-aversive methods for handling mice. Includes tutorials, FAQs and tips for implementation.

Three black mice, one of them is being handled with a clear plastic tunnel

Guidelines on implementing the 3Rs in both field and captive studies.

Two wild frogs
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Two laboratory technicians looking at a sample

Approaches for sampling blood in the ferret, covering surgical and terminal techniques.

Close up of a brown and white ferret's face, with an icon of a needle and syringe on a yellow background in the corner of the image.

The positive impact playpens have on laboratory rat welfare, and guidance on how to set one up in your institution.

A tall cage which has been used to create a rat playpen. There are three different tiers with ladders to allow the rats to climb up between each one. A number of white rats can be seen moving between the different levels. Enrichment and play objects are available on each level including an cardboard box that used to hold laboratory gloves, coloured balls, tubes, a wheel and a raised platform on the top level with some bedding material.