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61 results

aTRACKtive: Developing methods to identify individual mice from birth

Contractor: Dr Adam Polak, Fraunhofer UK Research Ltd , Fraunhofer UK Research Ltd

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T-ALERT: Developing an in vitro assay to evaluate the tumourigenicity of human engineered T cell therapies

Contractor: Professor Toni Cathomen, University of Freiburg

CRACK IT Challenge

Thyroid Tox: Developing a QSAR and molecular docking tool to predict thyroid receptor-mediated human endocrine disruption

Contractor: Dr Paul Thomas, KREATiS

CRACK IT Challenge

Thyroid Tox Challenge image of molecules

Virtual Second Species: Applying advanced computational and mathematical modelling approaches to develop a suite of virtual dog tissues and organs to model toxicological endpoints for new chemical entities

Contractor: Dr Stephan Schaller, esqLABS GmbH

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Virtual Second Species Challenge image of abstract network on a blue background

SAFE: Developing a suite of innovative bioassays to replace in vivo fish studies in chemical safety screening and regulatory environmental risk assessment.

Contractor: Dr Stephan Fischer, aQuaTox-Solutions GmbH

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STRATIS: A human-relevant in vitro or ex vivo platform that recapitulates the complex structures of skeletal muscle and the pathology of significant injury to them.

Contractor: Professor Mark Lewis, Loughborough University

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Animal-free in vitro: Adapting established Organisation for Economic Development Test Guideline in vitro assays so that they are free from animal-derived products

Contractor: Dr Victoria Hutter, ImmuOne Ltd

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Animal free in vitro Challenge image of test tubes

In vitro TDAR: Developing a human in vitro T-cell dependent antibody response (TDAR) assay to assess immune enhancement

Contractor: Dr Karla Queiroz, Mimetas B.V.

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Challenge 35 in vitro TDAR image of antibodies

MouseMApp: An application to monitor the welfare of mice

Contractor: Dr Matt Leach, Newcastle University

CRACK IT Challenge

MouseMAPP Challenge image of a mouse in a pair of hands

Tat-Fit: Developing a method that allows tamoxifen to be added to rodent chow without changing its palatability or consumption by the animals

Contractor: Dr Fang Liu, Fluid Pharma Ltd

CRACK IT Challenge

Tat fit Challenge image of mouse in cage

Sharp and to the Point: Developing a device for injections in mice that avoids the re-use of needles

Contractor: Mr Ian Quirk, Active Needle Technology Ltd

CRACK IT Challenge

A white mouse being held by a hand wearing a blue glove

CleanCut: Developing a human in vitro model to assess the safety of gene edited human haemopoietic stem cells

Contractor: Dr Alessandro Rotilio, MOAB srl

CRACK IT Challenge

Developing an automated apparatus for continual trials recognition memory in rodents

Contractor: Dr Alex Easton, Durham University

CRACK IT Solution

An apparatus that includes a testing chamber in which the white mouse can explore objects and includes a holding chamber

Moshers: Mouse Smart Hoppers

Contractor: Dr Lawrence Moon, Research Devices Ltd

CRACK IT Challenge

Validating CombiDART in the agrochemical sector

Contractor: Professor Alison Woollard, University of Oxford

CRACK IT Solution

Two non-vertebrate model systems, the nematode C. elegans and the social amoeba Dictyostelium discoideum to rapidly assess compounds for DART.

ImmuLiver – An immunologically-competent in vitro model of the human liver for the assessment of Yellow Fever vaccine attenuation

Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd

CRACK IT Challenge

RaTS - Developing a device for objective monitoring of rheumatoid arthritis progression in rodents

Contractor: Associate Professor Martin Hedegaard, University of South Denmark (SDU)

CRACK IT Challenge

X-ray of left and right hand showing joint inflammation from Rheumatoid arthritis

DARTpaths: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects

Contractor: Professor Raymond Pieters, University of Applied Sciences Utrecht (UASU)

CRACK IT Challenge

A new sensor platform combining plastic antibodies with simple thermal detection

Contractor: Dr Marloes Peeters, Manchester Metropolitan University

CRACK IT Solution

Sensor platform combining plastic antibodies with simple thermal detection

Development and evaluation of the Animal Welfare Assessment Grid (AWAG)

Contractor: Mr Mike Dennis, Public Health England

CRACK IT Solution

Parameter diagram breakdown, procedural is greater then psychological