Sharp and to the Point: Developing a device for injections in mice that avoids the re-use of needles Contractor: Mr Ian Quirk, Active Needle Technology Ltd, CRACK IT Challenge
Developing an automated apparatus for continual trials recognition memory in rodents Contractor: Dr Alex Easton, CRACK IT Solution
Validating CombiDART in the agrochemical sector Contractor: Professor Alison Woollard, CRACK IT Solution
DARTpaths: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects Contractor: Professor Raymond Pieters, University of Applied Sciences Utrecht (UASU), CRACK IT Challenge
Development and evaluation of the Animal Welfare Assessment Grid (AWAG) Contractor: Mr Mike Dennis, Public Health England, CRACK IT Solution
RespiraTox: In silico model for predicting human respiratory irritation Contractor: Dr Sylvia Escher, Fraunhofer ITEM, CRACK IT Challenge
Validating the cross-species comparative in silico platform (CRISP) Contractor: Dr Will Krawszik, CRACK IT Solution
Retinal 3D: 3D hiPSC derived laminated retinal model as a tool for toxicology studies Contractor: Professor Lyle Armstrong, Newcells Biotech Ltd, CRACK IT Challenge
Osteo-chip: Microfluidic Automated Platform for Osteoarthritis Drug Screening (MA-PODS) Contractor: Professor Anne Dickinson, Alcyomics Ltd, CRACK IT Challenge
Non-invasive in vivo tissue imaging with functional optical coherence tomography (OCT) Contractor: University of Washington, CRACK IT Solution
Maximise: Integrated web platform for agro-chemical formulation toxicity classification and data sharing Contractor: Professor Jonathan Timmis, SimOmics Ltd, CRACK IT Challenge
Neuroinflammation and nociception in a dish Contractor: Professor Adalberto Merighi, CRACK IT Solution
EASE: Design, Fabrication and Testing of a Mouse Embryo Culture Chip Contractor: Dr Virginia Pensabene, University of Leeds, CRACK IT Challenge
Using chicken eggs to advance the 3Rs in cancer drug discovery Contractor: Dr Jean Viallet, CRACK IT Solution
TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Demuris) Contractor: Dr Olivia Champion, CRACK IT Solution
TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Envigo) Contractor: Dr Olivia Champion, CRACK IT Solution
Metaboderm: 3D hiPSC derived skin model and in-silico skin modelling of metabolism Contractor: Newcells Biotech Ltd, CRACK IT Challenge
InMutaGene: A human IPS cell model for gene therapy vector safety evaluation Contractor: GeneWerk GmbH, CRACK IT Challenge
Comprehensive target screening by label-free cell microarray profiling to reduce animal efficacy and toxicology studies in drug discovery Contractor: Dr James Sidaway, CRACK IT Solution